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News tips from the Journal of Neuroscience

truding antiporter gene family with the interesting acronym TEXAN. Accordingly, Caudle et al. examined whether reduced VMAT2 leads to degeneration of dopamine neurons. The authors examined mice that expressed 5% of the normal protein (VMAT2 LO). These mice showed elevated reactive oxygen species, age-related neurodegeneration in the striatum, reduced striatal dopamine levels, and a corresponding decrease in locomotor behavior. By 18 months, VMAT2 LO mice had lower striatal tyrosine hydroxylase due to loss of DA neurons, and substantia nigral neurons contained levels of a-synuclein associated with Parkinsons disease (PD) pathology. Thus, compromised VMAT2 may increase susceptibility to PD and other neurodegenerative conditions.


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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
24-Jul-2007


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