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News tips from the Journal of Neuroscience

val factor Myo-GDNF (myogenin glial cell line-derivedneurotrophic factor), and chick embryosparalyzed by treatment with curare. All animals had an excess of axons projecting to target muscles, but motoneurons were smaller, and many axons failed to myelinate or form functional synapses. The phenotypes of the three animal models also differed in some features, consistent with distinct compensatory changes.

3. Orientation Tuning in Macaque Somatosensory Cortex

Pramodsingh H. Thakur, Paul J. Fitzgerald, John W. Lane, and Steven S. Hsiao

Previous work has shown that many neurons in the second somatosensory (S2) cortical region show orientation tuning, somewhat akin to that observed in the visual cortex. This week Pramodsingh et al. honed in on a single finger pad of two rhesus monkeys and show that this orientation tuning involves multiple mechanisms. They indented the skin of a finger pad with a motorized bar at eight different orientations and nine different locations and recorded from single neurons in the macaque S2 region. Some cells had simple cell-like receptive fields, but many neurons showed position invariant responses. That is, their firing was selective for a narrow band of orientations, and the preferred orientation was the same in any location across the finger pad. The range of response properties indicated that tuning results from a region of pure position invariance, bands of excitation and inhibition that are not centered on the finger pad, or a combination of these mechanisms.

4. Adenosine A2A Receptors and L-DOPA-Induced Dyskinesias

Danqing Xiao, Elena Bastia, Yue-Hang Xu, Caroline L. Benn, Jang-Ho J. Cha, Tracy S. Peterson, Jiang-Fan Chen, and Michael A. Schwarzschild

Treatment of Parkinson's disease with L-3,4- dihydroxyphenylalanine (L-DOPA) has its limits. Continued treatment often leads to adaptive behavio
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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
26-Dec-2006


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