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News tips from the Journal of Neuroscience

nsgenic expression of A causes striking pathology in C. elegans, such as muscle paralysis and problems with chemotaxis, which were alleviated by EGb 761. Rescue of these behaviors was accompanied by a reduction in A oligomers. The beneficial effects of G. biloba are thought to result from neuroprotective and antioxidant properties. But in the transgenic C. elegans, reducing oxidative stress with the antioxidant L-ascorbic acid was not nearly as effective in suppressing paralysis as EGb 761. Thus, the beneficial effects of the extract may result from block of A oligomerization.


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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
12-Dec-2006


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