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News tips from the Journal of Neuroscience

cording to Hines et al. this week, a gene encoding a brain-specific adenylyl cyclase may help explain this gender difference. Based on evidence pointing to a role for cAMP signaling in depression, the authors genetically manipulated the AC7 isoform of adenylyl cyclase in the brains of mice, and then assayed the animals for depression, i.e., immobility on the forced swim test and the tail suspension test. Female, but not male, AC7 transgenic or knockdown mice had respectively more or less depressive-like behavior than controls. But what is true for mice does not always apply to humans. In this case, however, the authors also report an association between polymorphisms in the human AC7 gene and an increased risk in women for familial depression, defined as a history of depression in a first-degree relative.


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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
28-Nov-2006


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