HOME >> BIOLOGY >> NEWS
News tips from the Journal of Neuroscience

1. Probing Repetitive Firing in Pyramidal Neurons
Steven A. Prescott, Stéphanie Ratté, Yves De Koninck, and Terrence J. Sejnowski

In response to a continuous stimulus, some neurons slow their firing rate, an adaptation process that is mediated by slow, voltage-dependent potassium channels such as IM and IAHP. This week, Prescott et al. show that adaptation can be modulated by membrane conductance, or shunting, as occurs with background synaptic activity. In experiments and simulations, adaptation was sufficient to interrupt firing in CA1 pyramidal neurons when membrane conductance was high, but firing persisted when conductance was low. According to their model, shunting, by increasing the voltage threshold for spike generation, also enhances subthreshold activation of IM, which in turn abolishes repetitive firing. Because adaptation can minimize background spiking, the nonlinear interaction between shunting and adaptation can make for a more precise neuronal response at low firing rates by acting like a coincidence detector rather than an integrator.


2. A Well-Rounded View of the Fly Synapse
Natasha M. Viquez, Caroline R. Li, Yogesh P. Wairkar, and Aaron DiAntonio

Fly fishing in St. Louis can be quite interesting it appears. This week, Viquez et al. went fishing for regulators of the Drosophila neuromuscular junction (NMJ) and pulled out a subunit of protein phosphatase 2A (PP2A), a serine threonine phosphatase required for many cellular processes. The authors generated >2500 transposable P-element insertion lines in which the yeast upstream activating sequence promoter was randomly inserted into the fly genome. After selecting lines with altered synapse morphology, they identified four in which the P-element insertion was positioned to overexpress the gene encoding the regulatory B′ subunit of PP2A. Null mutants of the gen
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
5-Sep-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/6/2017)... , April 6, 2017 ... RFID, ANPR, Document Readers, by End-Use (Transportation & Logistics, ... Facility, Oil, Gas & Fossil Generation Facility, Nuclear Power), ... Educational, Other) Are you looking for a ... sector? ...
(Date:4/5/2017)... , April 5, 2017 Today ... announcing that the server component of the HYPR platform ... for providing the end-to-end security architecture that empowers biometric ... HYPR has already secured over 15 million users ... including manufacturers of connected home product suites and physical ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):
(Date:10/9/2017)... ... October 09, 2017 , ... At its national board meeting in North Carolina, ... Harvard University’s Departments of Physics and Astronomy, has been selected for membership in ... team for the 2015 Breakthrough Prize in Fundamental physics for the discovery of the ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... applications consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding ... offers a broad range of contract analysis services for advanced applications. Services ...
(Date:10/6/2017)... ... 06, 2017 , ... The HealthTech Venture Network (HTVN) is ... fourth annual Conference where founders, investors, innovative practitioners and collaborators are invited to ... showcasing early stage digital health and med tech companies. , This day-long event ...
(Date:10/5/2017)... ... , ... Understanding the microbiome, the millions of bacteria that live in our ... My Future, the newest exhibit on display at the University City Science Center’s Esther ... the lens of the gut microbiome. , Gut Love opens October 12, 2017, ...
Breaking Biology Technology:
Cached News: