News tips from the Journal of Ne...( centrations of catecholamines in adrena...)

News tips from the Journal of Neuroscience

centrations of catecholamines in adrenal chromaffin cells and L-DOPA-treated PC12 cells. Overexpression of wild-type or mutant α-synucleins increased cytosolic catecholamine concentrations to levels that could overwhelm the capacity of neurons to buffer against the oxyradicals produced by dopamine oxidation. Addition of α-synucleins to isolated chromaffin granules disrupted the vesicular pH gradient, indicating that the observed increase in cytosolic catecholamine resulted from the leaking of neurotransmitter from vesicles. Mutant α-synucleins produced a greater increase in cytosolic neurotransmitter than their wild-type counterpart, possibly because of their propensity to produce membrane-damaging protofibrils.

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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
5-Sep-2006

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