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News tips from the Journal of Neuroscience

et al. examined the location of these GABAA receptor subunits in mice rendered epileptic by pilocarpine treatment, a standard animal model of temporal lobe epilepsy. Postembedding immunogold labeling confirmed a perisynaptic decrease in the subunit in dentate granule cell dendrites within the molecular layer. However, physiological studies found that tonic inhibition was still present. The 2 subunits shifted toward perisynaptic locations in the epileptic mice in parallel with a decrease in phasic inhibition. The authors suggest that receptors containing 4 and relocated 2 may underlie tonic inhibition in the epileptic mice.


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Contact: Sara Harris
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Society for Neuroscience
10-Jul-2007


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