News tips from the Journal of Neuroscience

Transporting Components to the Active Zone
Qian Cai, Ping-Yue Pan, and Zu-Hang Sheng

If you are planning to ship Piccolo, Bassoon, and a bit of N-cadherin and SNAP- 25, you will need some syntabulin, according to Cai et al. this week. Piccolo and its active zone (AZ) compatriots are transported by a complex, which includes syntaxin-1, the kinesin motor KIF5B, and the adaptor protein syntabulin. In fetal rat brains, vesicles containing presynaptic AZ components colocalized with this protein complex. Time-lapse imaging confirmed the colocalization and comovement of these proteins in cultured hippocampal neurons. After RNAi-induced depletion of syntabulin, or use of dominantnegative constructs that interfered with the KIF5B motor complex, GFP (green fluorescent protein)-labeled Bassoon accumulated at the nucleus rather than moving down axons along microtubules. Transport of the AZ precursor vesicles via the syntaxinsyntabulinKIF5B complex was essential for inclusion of AZ components into functional synapses and the activity-dependent recruitment of new presynaptic boutons.

Rats on Ritalin
Jason D. Gray, Michael Punsoni, Nora E. Tabori, Jay T. Melton, Victoria Fanslow, Mary J. Ward, Bojana Zupan, David Menzer, Jackson Rice, Carrie T. Drake, Russell D. Romeo, Wayne G. Brake, Annelyn Torres-Reveron, and Teresa A. Milner

When it comes to drug treatment of children with methylphenidate (MPH; Ritalin) for attention deficit/hyperactivity disorder (ADHD), ongoing debates are everywhere. One question is whether block of monoamine transporters with this drug leads to lasting alterations in the brain. This week, Gray et al. dosed male rats twice weekly between postnatal day 7 (PND7) and PND35 and then tracked immunocytochemical markers out to PND135. In adult rats, the 4 weeks of postnatal treatment decreased anxiety-like behavior on the elevated plus-maze task. At PND35, but not PND135, MPH-treated rats also showed incr

Contact: Sara Harris
Society for Neuroscience

Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years
11. News tips from the Journal of Neuroscience

Post Your Comments:

(Date:5/21/2020)... ... May 19, 2020 , ... ... operations management solutions, today introduced BioMed to their award-winning computerized maintenance management ... connecting the people and systems around biomedical engineering to better allocate staff ...
(Date:5/21/2020)... (PRWEB) , ... May 21, 2020 , ... ... care across the North Shore and Greater Boston area, is pleased to announce ... As one of the busiest group practices in the area, Agility Orthopedics is ...
(Date:5/14/2020)... ... May 13, 2020 , ... DuPont ... latest enzyme for the lactose-free dairy market. This unique product allows for process ... dairy products at competitive costs across North America. , Among the numerous benefits ...
Breaking Biology News(10 mins):
(Date:5/26/2020)... MENLO PARK, Calif. (PRWEB) , ... May 26, 2020 , ... ... Genie , the most recognized brand of smart garage door openers, announce a new ... full line of Wi-Fi enabled garage door openers powered by Aladdin Connect® can now ...
(Date:5/21/2020)... Prairie, MN (PRWEB) , ... May 19, 2020 , ... ... to help patients get dental implants and bone grafting through PIEZOSURGERY® technology. ... tissues. This is often used to prepare a patient for dental implants, especially when ...
(Date:5/21/2020)... REDWOOD CITY, Calif. (PRWEB) , ... May 20, ... ... to announce the addition of Simon Prakash, who will serve as the company’s ... Simon joins at a time when Exo is disrupting the medical imaging space, ...
(Date:5/15/2020)... ... May 14, 2020 , ... Children with defective heart ... before becoming adults. The reason: there are no heart valve prosthetics designed ... the Department of Defense has awarded Draper, Boston Children’s Hospital and Seattle Children’s ...
Breaking Biology Technology:
Cached News: