News tips from the Journal of Ne...( cus) of up to 24 hours. The seizures we...)

News tips from the Journal of Neuroscience

cus) of up to 24 hours. The seizures were followed by degeneration of ipsilateral CA3, hilar, and CA1 neurons, but apparently complete behavioral recovery. GCD was evident within 7 d, and chronic spontaneous epileptic discharges began 2 weeks after injection. However, the GCD did not appear to result from increased neurogenesis. Reelin-expressing neurons decreased significantly in KA-injected mice, and an injection of a reelin-neutralizing monoclonal antibody caused GCDin control mice. The authors suggest that GCD occurs as a result of either misguided migration or displacement of mature neurons because of localized reelin loss.

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Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
25-Apr-2006

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