HOME >> BIOLOGY >> NEWS
News tips from the Journal of Neuroscience

1. Bending the Rules for Glutamate Receptors
Mark L. Mayer, Alokesh Ghosal, Nigel P. Dolman, and David E. Jane

This week, Mayer et al. literally stretch our structural understanding of ionotropic glutamate receptors (GluRs). The bi-lobed, clamshell configuration of the ligand-binding core of ionotropic glutamate receptors mostly has been investigated using S1S2 domains crystallized with agonist. The extracellular S1 and S2 domains envelop agonists with the extent of closure presumably important to channel gating. The authors report the crystal structure of the kainate receptor GluR5 bound to the novel, high-affinity antagonists UBP302 and UBP310. Crystal structures of GluR5UBP complexes showed a much more open conformation than other glutamate receptors, with GluR5UBP302 being the most extended. Although the authors were unable to crystallize the apolipoprotein (unbound) or resting form of GluR5 S1S2, their results suggest that kainate receptors undergo much larger conformation shifts than has been suggested by structural studies of AMPA receptors. Interestingly, large movements are the norm for their ancestors, the bacterial periplasmic binding proteins.

2. Forming the Deep Cerebellar Nuclei
Andrew J. Fink, Chris Englund, Ray A. M. Daza, Diane Pham, Charmaine Lau, Mary Nivison, Tom Kowalczyk, and Robert F. Hevner

This week, Fink et al. traced the origin of deep cerebellar nuclei (DCN) projection neurons to the rhombic lip, using transcription factors as markers. The DCN cells marched rostrally to the nuclear transitory zone (NTZ) in a subpial stream. Along the way, the cells expressed Pax6, Tbr2, and Tbr1 consecutively, a sequence much like developing neurons of the cerebral cortex. In organotypic cultures, the rhombic lip alone was sufficient to produce this cell population. A subset of the cells expressed reelin, a guidance factor for Purkinje cells, but reelin was not required for DCN migration. Tbr1, however, wa
'"/>

Contact: Sara Harris
sharris@sfn.org
202-962-4000
Society for Neuroscience
14-Mar-2006


Page: 1 2 3

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... Modality Solutions, a ... 2020 annual Inc. 5000 list. The list is the most prestigious ranking of the ... well, and for this year’s list, reported three-year revenue growth of 71 percent. ...
(Date:8/21/2020)... ... August 19, 2020 , ... The ... uniting life science, data science, informatics and IT leaders goes VIRTUAL and announces ... of uncertainty and change, Bio-IT takes the leadership role of keeping our life ...
(Date:8/7/2020)... , ... August 06, 2020 , ... ... industry, is pleased to announce that Eric Chen and Jessica Wong have joined ... Product Management & Strategy, respectively. , Eric Chen heads development efforts for Alucio’s ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... R3 Stem Cell International is now ... With 50 million stem cells total, patients may choose which extremities they would like ... arthritic joints (BMC Musculoskelet Disord. 2016). At R3 International, umbilical cord tissue is obtained ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and ... it did not take off as quickly as people initially expected, and where eSource ... capturing data electronically for clinical trials and then repurposing it for downstream analysis, at ...
(Date:7/18/2020)... ... 16, 2020 , ... “We are thrilled to deliver this new technology to ... of its kind on the market and we were pleased that the IFT jury ... traditional cultured ingredients, creating a natural way to extend the shelf life and improve ...
(Date:7/10/2020)... ... July 09, 2020 , ... ... (PTU) is commonly used to suppress pigment formation in zebrafish embryos, maintaining optical ... team led by Dr MA has been using the zebrafish model to investigate ...
Breaking Biology Technology:
Cached News: