News tips from the Journal of Neuroscience

1. Owls on the Prowl

Joseph F. Bergan, Peter Ro, Daniel Ro, and Eric I. Knudsen

The eyes and ears of the barn owl provide a formidable adversary for the barn mouse. To examine this elegant system, the precise alignment of topographical maps of visual and auditory space in the optic tectum can be perturbed with prism-containing goggles. Juvenile owls readily adapt their auditory maps under these conditions, but adults show much less plasticity. This week, Bergan et al. tested whether hunting live prey would enhance adult plasticity. Hunting enhanced the realignment of the auditory map as manifested by shifts in the tuning of the interaural timing difference. The live action also improved hunting performance.

2. Silencing Mutant Huntingtin Late in the Course

Miguel Daz-Hernndez, Jess Torres- Peraza, Alejandro Salvatori-Abarca, Mara A. Morn, Pilar Gmez-Ramos, Jordi Alberch, and Jos J. Lucas

This week, Daz-Hernndez et al. try to arrest Huntington's disease (HD) late in the course by silencing mutant huntingtin (htt) in a mouse model of HD (Tet/HD94). Despite progressive loss of motor coordination, striatal atrophy, and neuronal htt-positive inclusions, the Tet/HD94 mice do not show loss of striatal neurons until 17 months of age. At this late stage, the authors treated the conditional mutant mice with doxycycline to shut off expression of the htt transgene. After five additional months, "gene-off" mice showed improved motor performance, whereas untreated "gene-on" Tet/HD94 mice continued to worsen. The authors suggest that gene silencing even at a late stage could have therapeutic potential.


Contact: Sara Harris
Society for Neuroscience

Page: 1

Related biology news :

1. News tips from the Journal of Neuroscience
2. News tips from the Journal of Neuroscience
3. News tips from the Journal of Neuroscience
4. News tips from the Journal of Neuroscience
5. Tips from the Journals of the American Society for Microbiology
6. Journalists can register now for ECCO 14 -- the European Cancer Conference
7. Journal of Alzheimers Disease achieves significant impact factor
8. News tips from the Journal of Neuroscience
9. Highlights from the July 2007 Journal of the American Dietetic Association
10. News tips from the Journal of Neuroscience
11. Journal of Nuclear Medicines impact grows, remains consistently high over past 5 years

Post Your Comments:

(Date:4/5/2017)... April 4, 2017 KEY FINDINGS ... expand at a CAGR of 25.76% during the forecast ... the primary factor for the growth of the stem ... https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The global stem cell ... application, and geography. The stem cell market of the ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:10/7/2017)... ... October 06, 2017 , ... ... providing advanced instruments and applications consulting for microscopy and surface analysis, Nanoscience ... application consulting, Nanoscience Analytical offers a broad range of contract analysis services ...
(Date:10/7/2017)... , Oct. 6, 2017  The 2017 ... of three scientists, Jacques Dubochet, Joachim Frank ... developments in cryo-electron microscopy (cryo-EM) have ... within the structural biology community. The winners worked ... can now routinely produce highly resolved, three-dimensional images ...
(Date:10/6/2017)... ... October 06, 2017 , ... ... lunch discussion and webinar on INSIGhT, the first-ever adaptive clinical trial for glioblastoma ... Cancer Institute. The event is free and open to the public, but registration ...
(Date:10/5/2017)... ... October 05, 2017 , ... Understanding the microbiome, the ... in human health. Gut Love: You Are My Future, the newest exhibit on display ... as it explores the human condition through the lens of the gut microbiome. ...
Breaking Biology Technology:
Cached News: