HOME >> BIOLOGY >> NEWS
Nicotine rush hinges on sugar in neurons

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smokers high"

As with other questions involving good sensations, the answer appears to be sugar.

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotines arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it a landmark accomplishment for the fields of structural biology and neuronal cell signaling.

Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the studys findings.

The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons.

The results reveal an important role for the sugar molecules in such proteins.

Our studies fill a major gap in the field and set a new paradigm, said Lin Chen, associate professor of molecular and computational biology at USC.

Many existing theories, which do not consider sugars role, are probably incomplete, Chen said.

The debate over how signals pass from the outside of a cell to the inside is a long-standing one.

Some researchers had suggested that when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a conformational wave that propagates a signal through the protein body to the cell membrane, Chen said.

But the molecular basis of such a wave in nAChR or any other protein has not been clearly established.

Instead, the Chen groups study of crystal structure suggested a simple mechanical role for sugar mo
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
22-Jul-2007


Page: 1 2

Related biology news :

1. Nicotine: The link between cigarette smoking and kidney disease progression?
2. Nicotine exposure during development leads to hearing problems
3. Nicotine triggers the same brain reward circuitry as opiates
4. White blood cells are picky about sugar
5. Study shows cane sugar, corn sweeteners have similar effects on appetite
6. A spoonful of sugar helps your waistline go down
7. Novel sugar-to-hydrogen technology promises transportation fuel independence
8. New role for sugars: Research shows connections between sugar modifications in cells and cancer
9. Blood sugars manufacture limited by building blocks supply
10. Juiced-up battery fueled by sugar could power small portable electronics
11. Iowa State researchers improve soy processing by boosting protein and sugar yields

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/24/2017)... 2017 Janice Kephart , former ... Strategy Partners, LLP (IdSP) , today issues the ... Trump,s March 6, 2017 Executive Order: Protecting ... can be instilled with greater confidence, enabling the ... refugee applications are suspended by until at least ...
(Date:4/18/2017)... a global expert in SoC-based imaging and computing solutions, has developed ... the company,s hybrid codec technology. A demonstration utilizing TeraFaces ® , ... showcased during the upcoming Medtec Japan at Tokyo Big Sight April ... Vegas Convention Center April 24-27. ... Click here for an image of the M820 ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... October 10, 2017 , ... ... pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, today confirmed licensing rights ... (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in collaboration with Children’s Hospital ...
(Date:10/10/2017)... 2017 SomaGenics announced the receipt of a ... RealSeq®-SC (Single Cell), expected to be the first commercially ... microRNAs) from single cells using NGS methods. The NIH,s ... accelerate development of approaches to analyze the heterogeneity of ... techniques for measuring levels of mRNAs in individual cells ...
(Date:10/9/2017)... ... 2017 , ... The award-winning American Farmer television series will feature 3 Bar ... Tuesdays at 8:30aET on RFD-TV. , With global population estimates nearing ten billion ... continue to feed a growing nation. At the same time, many of our valuable ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... applications consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding ... offers a broad range of contract analysis services for advanced applications. Services ...
Breaking Biology Technology:
Cached News: