HOME >> BIOLOGY >> NEWS
Nicotine rush hinges on sugar in neurons

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smokers high"

As with other questions involving good sensations, the answer appears to be sugar.

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotines arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it a landmark accomplishment for the fields of structural biology and neuronal cell signaling.

Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the studys findings.

The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons.

The results reveal an important role for the sugar molecules in such proteins.

Our studies fill a major gap in the field and set a new paradigm, said Lin Chen, associate professor of molecular and computational biology at USC.

Many existing theories, which do not consider sugars role, are probably incomplete, Chen said.

The debate over how signals pass from the outside of a cell to the inside is a long-standing one.

Some researchers had suggested that when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a conformational wave that propagates a signal through the protein body to the cell membrane, Chen said.

But the molecular basis of such a wave in nAChR or any other protein has not been clearly established.

Instead, the Chen groups study of crystal structure suggested a simple mechanical role for sugar mo
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
22-Jul-2007


Page: 1 2

Related biology news :

1. Nicotine: The link between cigarette smoking and kidney disease progression?
2. Nicotine exposure during development leads to hearing problems
3. Nicotine triggers the same brain reward circuitry as opiates
4. White blood cells are picky about sugar
5. Study shows cane sugar, corn sweeteners have similar effects on appetite
6. A spoonful of sugar helps your waistline go down
7. Novel sugar-to-hydrogen technology promises transportation fuel independence
8. New role for sugars: Research shows connections between sugar modifications in cells and cancer
9. Blood sugars manufacture limited by building blocks supply
10. Juiced-up battery fueled by sugar could power small portable electronics
11. Iowa State researchers improve soy processing by boosting protein and sugar yields

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nicotine rush hinges sugar neurons

(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/24/2015)... Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of ... report to their offering. This report analyzes the ... the following Segments: Face Biometrics, and Voice Biometrics. The report provides ... Japan , Europe , ... Africa , and Latin America ...
(Date:3/23/2015)... 2015  In the 2014 fiscal year, irs.gov recorded ... This figure accounts for a fraction of the estimated ... Report, exceeds $11 billion globally. The polygraph has traditionally ... has occurred. Investor Mark Saint Juste along ... Paolella partnered to administer the test in a ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
(Date:4/1/2015)... April 1, 2015 Synthetic Biologics, Inc. ... for serious infections and diseases, with a focus ... data supporting the development of SYN-004, the Company,s ... (IV) antibiotics within the gastrointestinal (GI) tract and ... for the prevention of C. difficile ...
(Date:4/1/2015)... April 1, 2015  Spherix Incorporated (Nasdaq: ... the fostering and monetization of intellectual property, today ... held full service global investment bank specializing in ... industry note featuring Spherix. The report, ... Senior Analyst at Chardan, was published on March ...
(Date:4/1/2015)... The concept of “spot reducing” areas is ... Founder of Fasciology, Ashley Black, says that even the idea ... of having to wait for the whole fat system to ... to fat cooling procedures, the only well known way ... which is a highly invasive procedure.” It is common knowledge ...
(Date:4/1/2015)... National recruitment firm Slone Partners ... as Head of Sales at Optimal Medicine, an international ... , Allen brings over 20 years experience in healthcare ... of companies including Dell Services Healthcare, Medsphere Systems and ... perfect fit for accomplishing the goals Optimal Medicine had ...
Breaking Biology Technology:Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 2Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 3Synthetic Biologics' SYN-004 Clinical Data for Protection of Microbiome Selected for Poster Presentation at American Society of Microbiology 2015 4Chardan Capital Issues Industry Note Covering Spherix 2Chardan Capital Issues Industry Note Covering Spherix 3Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 2Hybrid Health Guru, Ashley Black, announces that her invention The FasciaBlaster™ rivals the “fat cooling” procedures that reduce exercise and diet resistant fat pockets. 3Slone Partners Fills Head of Sales at Optimal Medicine 2
Cached News: