HOME >> BIOLOGY >> NEWS
Nicotine rush hinges on sugar in neurons

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smokers high"

As with other questions involving good sensations, the answer appears to be sugar.

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotines arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it a landmark accomplishment for the fields of structural biology and neuronal cell signaling.

Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the studys findings.

The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons.

The results reveal an important role for the sugar molecules in such proteins.

Our studies fill a major gap in the field and set a new paradigm, said Lin Chen, associate professor of molecular and computational biology at USC.

Many existing theories, which do not consider sugars role, are probably incomplete, Chen said.

The debate over how signals pass from the outside of a cell to the inside is a long-standing one.

Some researchers had suggested that when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a conformational wave that propagates a signal through the protein body to the cell membrane, Chen said.

But the molecular basis of such a wave in nAChR or any other protein has not been clearly established.

Instead, the Chen groups study of crystal structure suggested a simple mechanical role for sugar mo
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
22-Jul-2007


Page: 1 2

Related biology news :

1. Nicotine: The link between cigarette smoking and kidney disease progression?
2. Nicotine exposure during development leads to hearing problems
3. Nicotine triggers the same brain reward circuitry as opiates
4. White blood cells are picky about sugar
5. Study shows cane sugar, corn sweeteners have similar effects on appetite
6. A spoonful of sugar helps your waistline go down
7. Novel sugar-to-hydrogen technology promises transportation fuel independence
8. New role for sugars: Research shows connections between sugar modifications in cells and cancer
9. Blood sugars manufacture limited by building blocks supply
10. Juiced-up battery fueled by sugar could power small portable electronics
11. Iowa State researchers improve soy processing by boosting protein and sugar yields

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Nicotine rush hinges sugar neurons

(Date:4/13/2015)... NEW YORK , April 13, 2015 /PRNewswire/ ... study by TechSci Research, "Global Biometrics Market Forecast & ... to register a CAGR of around 14% till ... various governments for large scale implementation and review ... technology and launch of new products with greater ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
(Date:5/5/2015)... ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: ... and Chief Executive Officer, will present live at ... May 7, 2015     TIME:  11:30 am ET/8:30 am ... the red "register/ watch presentations" button ... where investors are invited to ask the company ...
(Date:5/5/2015)... 2015 Research and Markets ( ... "Clinical Laboratory, Molecular Diagnostics and Genomic Testing ... - Global Version" report to their offering. ... area of molecular diagnostics and pharmacogenics hold the ... market that is moving out of the national ...
(Date:5/5/2015)... , May 5, 2015   Tocagen Inc. ... David R. Parkinson , M.D., a venture ... appointed to the board of directors of Tocagen. ... experience in oncology clinical development, including leading clinical ... global approvals of the cancer therapeutics Gleevec®, Femara®, ...
(Date:5/5/2015)... Synedgen Inc. is pleased to announce the ... , Dr. Nguyen brings to Synedgen critical regulatory expertise ... as it moves forward in the FDA regulatory processes ... years. Dr. Nguyen will lead the management of nonclinical ... that must be completed in order to initiate human ...
Breaking Biology Technology:ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2Global Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market Trends and Forecast 2015 to 2019 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4Synedgen Announces the Appointment of Regulatory Affairs Manager 2
Cached News: