HOME >> BIOLOGY >> NEWS
Nicotine rush hinges on sugar in neurons

When nicotine binds to a neuron, how does the cell know to send the signal that announces a smokers high"

As with other questions involving good sensations, the answer appears to be sugar.

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings news of nicotines arrival.

Structural biologist Raymond Stevens of The Scripps Research Institute, who was not involved in the study, called it a landmark accomplishment for the fields of structural biology and neuronal cell signaling.

Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the studys findings.

The study provides the first detailed look at part of the mouse nicotinic acetylcholine receptor (nAChR), one in a large and important group of molecules, known as ion channel proteins, that allow signals to pass between neurons.

The results reveal an important role for the sugar molecules in such proteins.

Our studies fill a major gap in the field and set a new paradigm, said Lin Chen, associate professor of molecular and computational biology at USC.

Many existing theories, which do not consider sugars role, are probably incomplete, Chen said.

The debate over how signals pass from the outside of a cell to the inside is a long-standing one.

Some researchers had suggested that when a chemical such as nicotine binds to an ion channel protein on the cell surface, the protein starts a conformational wave that propagates a signal through the protein body to the cell membrane, Chen said.

But the molecular basis of such a wave in nAChR or any other protein has not been clearly established.

Instead, the Chen groups study of crystal structure suggested a simple mechanical role for sugar mo
'"/>

Contact: Carl Marziali
marziali@usc.edu
213-740-4751
University of Southern California
22-Jul-2007


Page: 1 2

Related biology news :

1. Nicotine: The link between cigarette smoking and kidney disease progression?
2. Nicotine exposure during development leads to hearing problems
3. Nicotine triggers the same brain reward circuitry as opiates
4. White blood cells are picky about sugar
5. Study shows cane sugar, corn sweeteners have similar effects on appetite
6. A spoonful of sugar helps your waistline go down
7. Novel sugar-to-hydrogen technology promises transportation fuel independence
8. New role for sugars: Research shows connections between sugar modifications in cells and cancer
9. Blood sugars manufacture limited by building blocks supply
10. Juiced-up battery fueled by sugar could power small portable electronics
11. Iowa State researchers improve soy processing by boosting protein and sugar yields

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/11/2017)... , Jan. 11, 2017  Michael Johnson, co-founder of Visikol ... Capital Group, Inc., has been named to the elite "Forbes 30 ...  was one of 600 people in 20 fields nationwide to be ... of the 15,000 applicants were selected. ... He is currently a PhD candidate at Rutgers ...
(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., ... iris scanning technology for automotive at CES® 2017. Delta ... GNTX ) to demonstrate the use of iris scanning ... and authenticate the driver in a car, and as ... the driving experience. Delta ID and Gentex ...
(Date:1/3/2017)... 2017 Onitor, provider of digital health technology ... an innovative biometric data-driven program designed to aid weight ... the 2017 Consumer Electronics Show (CES) in ... U.S., the World Health Organization (WHO), have identified lifestyle ... who are overweight or obese. WHO also states that ...
Breaking Biology News(10 mins):
(Date:1/21/2017)... , Jan. 20, 2017 Aratana Therapeutics, Inc. ... focused on the licensing, development and commercialization of innovative ... Best Company in North America ... the award based on the FDA approval of ... tablets), ENTYCE ® (capromorelin oral solution) and NOCITA ...
(Date:1/20/2017)... January 20, 2017 http://www.Financialbuzz.com ... one of leading causes of death worldwide. There were ... number of cancer related deaths increased gradually over time, ... incidence rate of various cancers continues to drive demand ... report by Global Market Insights, Inc. cancer biological therapy ...
(Date:1/19/2017)... , Jan. 19, 2017 /PRNewswire -- WuXi AppTec, ... open-access capability and technology platform, today announced that ... biology focused preclinical drug discovery contract research organization ... become a wholly-owned subsidiary of WuXi, and will ... and providing greater services. The acquisition will further ...
(Date:1/19/2017)... 2017  ArmaGen, Inc., today announced that it ... chief executive officer, as well as a member ... ArmaGen more than 17 years of executive management ... biotherapeutics and pharmaceuticals. "Mathias is ... and skillset necessary to lead ArmaGen to its ...
Breaking Biology Technology:
Cached News: