HOME >> BIOLOGY >> NEWS
Nodal status is best predictor of outcome after neoadjuvant therapy for esophageal cancer

The number of lymph nodes that contain evidence of cancer is the best predictor of the effectiveness of adding chemotherapy and radiation to a treatment plan prior to surgery in individuals with oesophageal cancer, according to a study published last month in the Annals of Surgery. The authors say their finding is particularly important because the focus of recent pathological studies of response to neoadjuvant therapies has been on the primary tumour rather than nodal sites.

Multimodal neoadjuvant therapy---where suitable patients are given several cycles of drugs and radiation therapy before undergoing surgical procedures to remove their tumour---is increasingly being used by oncologists as a way to boost survival rates from oesophageal cancer which, even with the most radical surgery, remain low: only 50% of patients survive for 3 years. However, the evidence for which additional therapies work best is confusing and conflicting. What is more, although it is widely accepted that there is a group of patients in whom this approach works well, identifying who these patients are is no easy task.

To help find ways of pinpointing individuals who might respond best to neoadjuvant treatment, John Vincent Reynolds and colleagues followed the progress of 243 patients who were treated with chemotherapy and radiation before surgery over 5 years. They paid particular attention to the histomorphological responses of patients---changes in the structure and appearance of tissue samples when viewed under a microscope---in addition to assessing prognosis using the traditional TNM method of staging, which takes into account tumour size, involvement of lymph nodes (nodal status), and presence or absence of metastases.

The study group consisted of all patients undergoing neoadjuvant treatment for oesophageal cancer at St James Hospital in Dublin,Ireland. Patients with oesophageal cancer were deemed suitable for multimodal therapy if they fulfilled
'"/>

Contact: Corinne Hall
mediaservice@esoncology.org
39-028-546-4522
European School of Oncology
13-Jul-2007


Page: 1 2 3

Related biology news :

1. MU researchers to study the status of black bears in Missouri
2. Green sturgeon receives threatened status
3. High-status monkeys ignore the interests of riff-raff
4. Genomatix Microarray Analysis Pipeline achieves Affymetrix GeneChip compatible status
5. Sudden change in social status triggers genetic response in male fish, study finds
6. Manatee eyes could be window to health status
7. Location, location, location: Effect of nuclear organization on transcriptional status
8. Biologists findings on fertility and status in monkeys generate scientific, media interest
9. MIDI, Inc receives Official Methods(SM) status for the confirmatory ID of the anthrax pathogen
10. Study in Royal Society journal on how relationship status influences sex ratios
11. DNA highly promising predictor for successful treatment of alcoholics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... 11, 2017 Crossmatch®, a globally-recognized leader ... today announced that it has been awarded a ... Activity (IARPA) to develop next-generation Presentation Attack Detection ... "Innovation has been a driving force within Crossmatch ... allow us to innovate and develop new technologies ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... USDM Life Sciences , the leading ... healthcare industries, is pleased to announce Holger Braemer as Vice President of ... GmbH” based in Germany. , Braemer is an integral part of USDM’s expansion ...
(Date:4/20/2017)... ... , ... Parallel6™ , the leader in mClinical™ technologies for improving patient ... one of the 2017 Top 10 eClinical Trial Management Solution Providers by Pharma ... “We take pride in honoring Parallel6 as one of the top 10 companies that ...
(Date:4/19/2017)... ... April 18, 2017 , ... The Vibrating Orifice Aerosol Generator ... generating monodisperse droplets of known diameters for research applications such as for calibrating ... by drying monodisperse droplets. , The VOAG requires forcing liquid out of ...
(Date:4/19/2017)... , ... April 19, 2017 , ... ... Series A-1 financing round. This event adds to several other early achievements at ... Executive and Scientific Teams. , ThermaGenix will use proceeds from the ...
Breaking Biology Technology:
Cached News: