HOME >> BIOLOGY >> NEWS
Non-coding RNAs help silence the mammalian transcription

Dr. Shirley Tilghman and colleagues (Princeton University) lend new insight into the mechanism of genomic imprinting, demonstrating a necessary role for a non-coding RNA transcript in the silencing of an imprinted gene cluster in mice.

Imprinting, or the differential expression of a gene based upon which parent it has been inherited from, is integral to normal growth and development. Two human disorders, Prader-Willi and Angelman syndromes, result from the deletion of the identical portion of chromosome 15. Imprinting determines which disorder arises: When the deletion involves the chromosome 15 that came from the father, the child has Prader-Willi syndrome, but when the deletion involves the chromosome 15 that came from the mother, the child has Angelman syndrome.

In the mouse, a cluster of nine genes on the distal end of the number 7 chromosome is imprinted. Dr. Tilghman and colleagues made a series of targeted alterations to ascertain which sequences are responsible for their paternal-specific silencing. The researchers show that this imprinted gene silencing requires the elongation of a paternally-expressed non-coding RNA transcript, Kcnq1ot1.

"As we explore the mechanism of genomic imprinting in greater detail, it is becoming clear that there is not a single explanation for the silencing of all imprinted genes. Rather mammals have co-opted multiple transcriptional regulatory mechanisms that were already evolved. In the case of the Kcnqt1ot1, the mechanism utilizes some form of RNA silencing. The variation in silencing mechanisms lends further support to the argument that imprinting arose gradually over a long period in mammals, not all at once," explains Dr. Tilghman.


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-May-2006


Page: 1

Related biology news :

1. Insulator helps silence genes in dormant herpes virus
2. MIT: Pulsing light silences overactive neurons
3. Light-activated compound silences nerves, may one day help epileptics
4. Lost cuckoo breaks its silence
5. Speechless and Mute help break the silence of the leaves
6. Commonplace sugar compound silences seizures
7. Interfering RNA silences genes in slippery immune cells
8. Researchers find protein that silences genes
9. Restoring silenced suppressor gene kills lung-cancer cells
10. Epigenetic activity silences Rb2/P130 gene in lung cancer
11. Human cells can silence HIV genes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/1/2020)... ... ... More than 600 people undergo genetic counseling and testing each year as ... two genetic counselors. , My Gene Counsel , a digital health company that ... Rick Program to ensure that UConn’s patients who have undergone genetic testing for cancer ...
(Date:4/30/2020)... ... 29, 2020 , ... At the start of 2020 ... for a wide range of industries including pharmaceutical and biopharmaceutical manufacturing, healthcare, food ... new decade, it was clear to company leadership that they would have to ...
(Date:4/26/2020)... NEW YORK (PRWEB) , ... April 23, 2020 , ... ... collaboration with GenScript, is developing a synthetic antibody to SARS-CoV-2, the virus that causes ... lung cells, and would be another potential treatment option for COVID-19. , The efforts ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... , ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company developing novel approaches to ... Ganz will continue to lead Sentien’s Board of Directors, a role he has filled ... and Sentien’s management team. , Mr. Ganz has more than 30 years ...
(Date:5/14/2020)... , ... May 13, 2020 , ... ... assays or phenotypic readouts, providing little or no information on the drug’s mechanism ... more comprehensive characterization of compounds by measuring the activity of molecular pathways. This ...
(Date:5/5/2020)... Fla. (PRWEB) , ... May 05, 2020 , ... ... and solutions company, announced today the launch of its iGlucose® LTE ... new iGlucose solution utilizes LTE Cat-M1 technology, the industry’s newest and broadest cellular ...
(Date:4/22/2020)... and CAMBRIDGE, Mass. (PRWEB) , ... April 20, ... ... Budapest with US offices in Cambridge, MA, announced today that Omixon’s founder and ... the early commercialisation of Omixon’s flagship product Holotype HLA since 2014 before stepping ...
Breaking Biology Technology:
Cached News: