HOME >> BIOLOGY >> NEWS
Novel approach to cancer drug given major boost

Scientists at the ProXara Biotechnology Limited have identified a way of switching off one of the key mechanisms that leads to the development and growth of a tumour. Under the Wellcome Trust's Seeding Drug Discovery initiative, the researchers hope to use their findings to develop a drug which could be used to fight cancer. The funding will be used to develop the drug to a point at which it is close to entering a clinical trial.

All cells in the body contain protein kinase B (PKB), a naturally-occurring enzyme that if active prevents cells from committing suicide. Programmed cell death, or apoptosis, is an important process in the body's development, but when this process goes wrong, unregulated cell growth occurs, leading to the development of tumour cells.

Recent research has shown that certain types of genetic damage, common to many cancer cells, lead to the movement of PKB from the interior of the cell to its surface membrane. When PKB attaches to the surface membrane, it becomes active, triggering a signal that tells the cell not to commit suicide. Professor Jeremy Tavar at ProXara Biotechnology Ltd, a spin-out company at the University of Bristol, believes that by preventing PKB binding to the cell's surface membrane, he can ensure that apoptosis occurs, thus killing the cancer cells.

"There has been a lot of interest in targeting PKB as a way of preventing tumour growth," says Professor Tavar. "Most of the interest so far has been in developing drugs that block the enzyme's signal. However, such drugs are very non-specific and can have many adverse side effects. We are working on a novel approach to prevent PKB actually binding to the cell membrane."

Professor Tavar and his team have discovered a drug-like compound, which prevents PKB binding to the cell membrane and makes the tumour cells commit suicide. They now wish to develop this compound to a point at which it could be used in clinical trials.

"Professo
'"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
14-Jan-2007


Page: 1 2

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel regulation of the common tumor suppressor PTEN
9. Novel EGFR ectodomain mutations in glioblastoma
10. Novel regulatory mechanism identified for key tumor suppressor p53
11. Novel experiment documents evolution of genome in near-real time

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... FREDERICK, Md. (PRWEB) , ... ... ... a leading provider of gene-to-protein and monoclonal antibody development services, today announced ... of protein-based products and services to the pharmaceutical, diagnostics, and research industries. ...
(Date:6/23/2020)... ... 23, 2020 , ... In its June 22 online post, business and technology ... Sherley, M.D., Ph.D., founder and director of stem cell biotechnology company Asymmetrex . ... that starting July 5 it would begin offering free tissue stem cell ...
(Date:6/13/2020)... ... 2020 , ... Bode Technology (Bode), a leading ... team. Bode’s Forensic Genealogy Service (FGS) continues to deliver investigative leads ... The team has added experienced genealogists, each having over a decade of field ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... eSource has long been ... webinar will cover the history of eSource, the reasons it did not take off ... wearables, to site source, the industry is moving towards capturing data electronically for clinical ...
(Date:7/31/2020)... , ... July 30, 2020 ... ... cloud-based software for the life sciences industry, today announced the release of ... designed specifically for Medical Science Liaisons (MSLs) and other field medical professionals. ...
(Date:7/18/2020)... (PRWEB) , ... July 16, 2020 , ... After research ... The completion of a great surgery is only the beginning of a successful study, ... research community. , Join Brad Gien, Global Head of Surgery from Envigo ...
(Date:7/18/2020)... DAYTON, Ohio (PRWEB) , ... July 16, 2020 ... ... clinical data solutions to aid in the early detection and prevention of high-burden ... partnership to enable US-based hospitals and healthcare organizations to utilize existing data in ...
Breaking Biology Technology:
Cached News: