HOME >> BIOLOGY >> NEWS
Novel approach yields predictions validated by experiments

Coming full circle has new meaning for researchers who demonstrated a promising new approach integrating scientific experimentation and mathematical modeling to study a key signaling pathway that helps cells decide whether to grow or die.

With implications for disease characterization, biotechnology and drug design, the approach tested by researchers at the Medical University of South Carolina (MUSC) and the Georgia Institute of Technology offers an efficient way of gaining useful knowledge from the massive amounts of complex biological information generated with today's advanced analysis technology.

The work represents another step toward modeling complex biological systems accurately enough to make useful predictions. "Our research went beyond describing a one-way street," said Professor Eberhard Voit of the Georgia Tech/Emory University Wallace H. Coulter Department of Biomedical Engineering. "Experimenters generate data, modelers design a mathematical model that fits the data, and often that's the end of the story. But, in this research, the experimenters actually tested hypotheses generated by the model, thus closing the circle."

Voit -- also a Georgia Research Alliance Eminent Scholar with expertise in mathematical and computational modeling -- reports this research with his MUSC colleagues in the Jan. 27, 2005 issue of the journal Nature. The researchers demonstrated their scientific approach within the context of sphingolipid metabolism in yeast. Sphingolipids are signaling molecules that assist cells in deciding whether to grow or die. Research has shown these molecules have implications in preventing several types of cancer in animal models. "We amassed an incredible amount of data from the literature and the lab on this particular metabolic pathway and integrated it all into one functioning entity -- the mathematical model," Voit explained. "This model now allows us to test 'what-if' scenarios and make predictions on experiments th
'"/>


26-Jan-2005


Page: 1 2 3 4

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel approach to cancer drug given major boost
9. Novel regulation of the common tumor suppressor PTEN
10. Novel EGFR ectodomain mutations in glioblastoma
11. Novel regulatory mechanism identified for key tumor suppressor p53

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/3/2020)... ... ... Board-certified oral and maxillofacial surgeon, Dr. Michael Noffze offers experienced wisdom ... Dr. Noffze can successfully extract problem and impacted wisdom teeth in teens and adults ... the oral and overall health of most patients as these extra teeth can cause ...
(Date:3/2/2020)... ... March 02, 2020 , ... Rigaku ... Conference on Analytical Chemistry and Applied Spectroscopy ( Pittcon 2020 ), being held ... world’s leading annual conference and exposition on laboratory science, attracting attendees from industry, ...
(Date:2/28/2020)... ... February 27, 2020 , ... Regen Suppliers is now ... rate PDO thread lift products are not only one of the only ... invasive thread lift procedures are increasing exponentially in popularity, as they represent an excellent ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... ... March 10, 2020 , ... Lifecycle Biotechnologies announced today that is ... to be used as a biopharmaceutical and biotechnology production and development campus. Lifecycle is ... well as its production and development hub. The company expects to relocate from Fort ...
(Date:3/2/2020)... ... March 02, 2020 , ... McBee, Moore and Vanik ... list in the field of Biotechnology and Organics. , According to statistics compiled by ... of 259 patents issued in technology center 1600 during 2019. Technology center 1600 at ...
(Date:2/21/2020)... (PRWEB) , ... February 20, 2020 , ... ... ensuring supply chain transparency and reassuring consumers that what’s listed on an ingredient ... trademarked ingredients, Nutrition21 has introduced this solution with the adoption of CertainT, which ...
(Date:2/19/2020)... ... February 19, 2020 , ... Red Nucleus, a leading provider ... announced the opening of a new office in Tokyo, Japan. The new office ... Nucleus announced the new office in response to customer requests for regional coverage. ...
Breaking Biology Technology:
Cached News: