Novel biomarker for prediction of survival in colorectal carcinomas revealed

CHICAGO -- Levels of a protein called thymidylate synthase (TS) within two separate compartments of a tumor cell--the nucleus and the cytoplasm--may be critical markers predicting survival in colorectal cancer, according to a study at Yale University School of Medicine.

The study revealed two different and independent predictors of survival in colorectal cancer. One was TS levels in the nucleus--the higher the levels, the lower the survival time; and one was the ratio of TS levels in the nucleus to levels in the cytoplasm--the higher the ratio, the lower the survival time.

"TS levels have been known as a marker for decreased survival and response to therapy, but this is the first study to show that the relationship between nuclear and cytoplasmic levels of TS can predict survival," said first author Mark D. Gustavson, Ph.D., a postdoctoral fellow in Yale's Department of Pathology.

Results were presented at the first meeting on Molecular Diagnostics in Cancer Therapeutic Development, organized by the American Association for Cancer Research.

To determine subcellular TS levels, Gustavson and his colleagues used AQUATM, a system that combines fluorescence-based imaging with automated microscopy and high-throughput tissue microarray technologies. Developed at Yale and licensed to HistoRx, AQUA can measure protein concentrations within specific cells and cellular compartments in a highly reproducible and unbiased manner, Gustavson said.

Working with tissue samples from 518 colorectal cancer patients diagnosed between 1970 and 1981, the researchers found that just 51 percent of patients with high TS levels in the nucleus survived for five years compared to 71 percent of those with lower levels. The difference was highly statistically significant. TS levels in the cytoplasm were also higher in patients with lower survival times, though they were not as strong a predictor of survival as TS levels in the nucleus

Contact: Warren Froelich
American Association for Cancer Research

Page: 1 2

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel approach to cancer drug given major boost
9. Novel regulation of the common tumor suppressor PTEN
10. Novel EGFR ectodomain mutations in glioblastoma
11. Novel regulatory mechanism identified for key tumor suppressor p53

Post Your Comments:

(Date:11/23/2018)... , ... November 23, 2018 , ... ... Emeran Mayer, MD, Executive Director of the G. Oppenheimer Center for Neurobiology of ... scientists and doctors from around the world, Dr. Mayer will bring to uBiome ...
(Date:11/20/2018)... ... ... Thanks to its long-standing expertise in ID reader development and industrialization, Elyctis is ... now proposes a full range of readers able to satisfy all needs including usage ... by professionals either in a fixed location or on the move as well as ...
(Date:11/16/2018)... PHILLADELPHIA (PRWEB) , ... November 16, 2018 , ... ... Jr., P.G., was awarded the International Bottled Water Association’s (IBWA’s) IBWA/Shayron Barnes-Selby ... week. , IBWA’s Advocacy Award, named “The Selby” after longtime IBWA contributor Shayron ...
Breaking Biology News(10 mins):
(Date:11/5/2018)... ... 05, 2018 , ... USARAD Holdings Inc., the leading US ... healthcare VC firms announces at Distributed Health 2018 conference November 5-6 (Nashville, TN) ... and obtaining its first radiology interpretations, one of the first known true use ...
(Date:11/3/2018)... ... 01, 2018 , ... Come to Princeton Nov. 14 and ... Division of Clinical Compliance Evaluation, CDER, FDA will be presenting on using data ... should clinical research industry stakeholders keep in mind when implementing and managing risk-based ...
(Date:10/31/2018)... ... 30, 2018 , ... Myoscience, Inc. announced today that it ... Memphis, Tennessee. This study enrolled 125 patients and compares the effect of ... after total knee replacement surgery (TKA). , The Myoscience iovera° system is currently ...
(Date:10/31/2018)... ... 2018 , ... Today, the National Corn Growers Association (NCGA) announced the launch ... to find new and innovative uses of field corn. NineSigma is serving as the ... of corn and are on pace to produce the second largest crop ever. One ...
Breaking Biology Technology:
Cached News: