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Novel biotoxin being studied for use in opioid withdrawal

odin, developed by Wex Pharmaceuticals Inc. (TSX:WXI), is derived from the puffer fish, also known as the blow fish. Studies have shown it to be fast acting, long lasting and non-addictive. It was originally developed for the clinical treatment of heroin withdrawal in China. It works by blocking slow sodium channel nocicipetive pain fibres in a highly selective way. Tetrodotoxin proved to have such good analgesic properties in the initial Chinese trials that it is also now being evaluated for clinical use in the treatment of refractory cancer pain.

"The results from this Phase IIa trial in patients on methadone should be known in 2005. "The study is going well. I expect early next year to know whether this works out or not. One could be hopeful that it represents a new treatment," Dr. Sellers said.


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Contact: Don Evans
don@wexpharma.com
604-676-7894
WEX Pharmaceuticals Inc.
18-Nov-2004


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