HOME >> BIOLOGY >> NEWS
Novel gene-silencing nanoparticles shown to inhibit Ewing's sarcoma

Anaheim, Calif. -- A novel delivery system that transports gene silencing nanoparticles into tumor cells has been shown to inhibit Ewing's sarcoma in an animal model of the disease.

In this classic "Trojan horse" approach, a protein called transferrin that normally delivers iron into cells is modified to also smuggle into tumor cells siRNA (short interfering RNA) encased in nano-sized sugar polymers. The siRNA was designed to target a specific growth-promoting gene called EWS-FLI1 that's active only in Ewing's sarcoma tumors.

Once inside these cells, the genetic machinery of the tumor cells are effectively silenced or shut down, preventing further growth.

"This is the first study to show that systemic administration of siRNA can inhibit disseminated tumor growth," said Siwen Hu, a postdoctoral fellow at Children's Hospital of Los Angeles and the University of Southern California, and one of the study's lead investigators.

"We conclude that this novel delivery system is a powerful and simple method to induce gene silencing, with the potential to move to clinical trials," said Hu, who presented the results at the 96th Annual Meeting here of the American Association for Cancer Research.

In recent years, scientists have been intrigued by the potential of siRNA to block the activity of genes that promote the growth of tumors. Harnessing the power of this new technology, however, has proved daunting for a variety of reasons, including the ability to deliver these bits of genetic material in high concentrations to specific tumor sites, while avoiding degradation.

To overcome these hurdles, the scientists employed a sugar-containing polymer invented by chemical engineers at the California Institute of Technology. For this experiment, the polymer binds to and condenses the engineered siRNA into nanoparticles that, in effect, form a protective shield around their precious genetic cargo. These nanoparticles, in turn, are attache
'"/>

Contact: Warren R. Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
19-Apr-2005


Page: 1 2 3

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel approach to cancer drug given major boost
9. Novel regulation of the common tumor suppressor PTEN
10. Novel EGFR ectodomain mutations in glioblastoma
11. Novel regulatory mechanism identified for key tumor suppressor p53

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2019)... Mass. (PRWEB) , ... September 23, 2019 , ... ... US offices in Cambridge, MA, announce today that Holotype HLA and other Omixon ... annual meeting of the American Society for Histocompatibility and Immunogenetics (ASHI) ...
(Date:9/24/2019)... ... September 24, 2019 , ... ... that it has received 300 five-star reviews on the popular travel review site, ... experience,” “amazing views and incredible food” and “unique local experience.” These sentiments have ...
(Date:9/17/2019)... ... September 17, 2019 , ... ... doctors, scientists and engineers from the Medical University of Warsaw, met at the ... work to-date in creating a neuroprosthetic system as part of an initiative called ...
Breaking Biology News(10 mins):
(Date:9/11/2019)... ... September 10, 2019 , ... An upcoming episode of ... developments in genome sequencing analysis. Check your local listings for more information. , ... Research & Consulting and will explore its revolutionary pathogenic DNA analysis technology, which ...
(Date:9/9/2019)... ... 09, 2019 , ... Visikol CEO Dr. Michael Johnson recently gave a ... to characterize 3D cell culture models. The inherent problem of characterizing 3D cell culture ... to image through and therefore traditional wide-field or even confocal microscopy only tells you ...
(Date:9/8/2019)... , ... September 05, 2019 , ... ... Blaine Fitzgerald, former Vice President of Finance for Shopify, has been named Chief ... and healthcare venture capitalist Joel Finlayson as strategic advisors. Additionally, Spartan has hired ...
(Date:9/2/2019)... ... September 02, 2019 , ... Diagenode, Inc., a ... launched the industry’s first epigenetics data mining services that uses unique algorithms and ... other data types. , Next generation sequencing in combination with bioinformatics analyses ...
Breaking Biology Technology:
Cached News: