HOME >> BIOLOGY >> NEWS
Novel mechanism for DNA replication discovered

Since the discovery of the structure of DNA by James Watson and Francis Crick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication. In other words, if a guanine base is on the original strand of DNA then its partner, a cytosine base, will pair to it on the replicated strand. In a study published in this week's issue of Science, researchers from Mount Sinai School of Medicine report on the first instance in which a protein, rather than the DNA, provides the coding information.

The study offers a specific mechanism by which cells cope with some of the most destructive carcinogens in the environment, including those in cigarette smoke. Many of these carcinogens preferentially damage DNA at guanine one of the four bases in DNA blocking, in some cases, the ability of the guanine to partner with cytosine, which can lead to mistakes during replication.

Aneel Aggarwal, PhD, and Deepak Nair, PhD, of the Department of Physiology and Biophysics at Mount Sinai School of Medicine and their colleagues at University of Texas Medical Branch, Galveston discovered that a protein called Rev1 DNA polymerase itself codes for a cytosine to be placed on the replicating strand. The cytosine is inserted based upon the coding information in Rev1 regardless of whether a guanine or another base is present on the DNA.

"This is the first time we have seen a protein serving as a template for DNA synthesis," said Dr. Aggarwal. "This provides an entirely new mechanism by which cells can replicate through DNA damaged by certain carcinogens. It thus opens a novel area of study with the potential for innovative approaches to prevention and treatment of cancer."


'"/>

Contact: Mount Sinai Press Office
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
29-Sep-2005


Page: 1

Related biology news :

1. Novel sugar-to-hydrogen technology promises transportation fuel independence
2. Novel system developed to turn data into real-time, interactive 3-D images
3. Novel strategies for healthy aging
4. Novel salamander robot crawls its way up the evolutionary ladder
5. Novel test identifies lymphoma patients likely to respond to new therapy
6. Novel laboratory technique nudges genes into activity
7. Novel approaches to tackling obesity, cancer and MRSA
8. Novel approach to cancer drug given major boost
9. Novel regulation of the common tumor suppressor PTEN
10. Novel EGFR ectodomain mutations in glioblastoma
11. Novel regulatory mechanism identified for key tumor suppressor p53

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel mechanism for DNA replication discovered

(Date:11/21/2014)... Calif. , Nov. 20, 2014 Strict ... driver efficiency are piloting the North American and European ... of accidents growing, gesture recognition systems that are intuitive ... a mark in the industry. New ... Automotive Gesture Recognition Market in Europe ...
(Date:11/18/2014)... Nov. 17, 2014   News ... collaborate to develop The Partners Data Lake, an ... Partners Data Lake will allow researcher and clinicians ... treatment and the lives of patients , ... clinical activities across the Partners system, breaking down ...
(Date:11/12/2014)... 2014 Crossmatch™, a leading provider of biometric ... fingerprint readers have been deployed throughout Montparnasse Pasteleria, ... Mexico . The bakery chain implemented the Crossmatch ... caused by employees clocking in for each other. ... Montparnasse relied on paper timecards and a mechanical time ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 Reports ... in the United States suffer from one or more ... asthma, or cancer. Medication can address some of these ... daily activities that many sufferers face. While implanted nerve ... and stimulate the whole nerve, which can induce side ...
(Date:12/19/2014)... With only 2 weeks left of ... Sartorius Biohit products . The product specials include Buy ... Pipette Trade-in Program, and free pipette tips. , Sartorius ... the world. They are ideal for lab technicians performing ... ,     Full volume range of 0.1 uL to ...
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, Inc. ... the treatment of chronic pain, announced the results of ... "This was a transformational year in Relmada,s history ... for our company," said Sergio Traversa , chief ... have executed on key financial, human resource and clinical ...
(Date:12/17/2014)... 2014 Achim Noack has been named ... Group. In this position, Noack will assist Jerry Stoller, ... develop marketing strategy and supervise global marketing management and ... has tremendous knowledge and experience in the crop protection ... experience and innovative thinking will be a great asset ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
Cached News: