HOME >> BIOLOGY >> NEWS
Nutritional genomics identifies a potential weight-loss resistance gene

Two obese people follow the same low-calorie diet and do not exercise, but one loses much more weight than the other. Genetic factors may explain this phenomenon, according to Jos Ordovas, PhD, director of the Nutrition and Genomics Laboratory at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University. In a study published in the Journal of Clinical Endocrinology & Metabolism, Ordovas and colleagues identified a variation in the perilipin gene that appears to render some people resistant to weight loss from calorie restriction. This research builds on their earlier work on perilipin and obesity.

"It is as if the connection between calorie intake and body weight is interrupted," explains Ordovas, who is also a professor at the Friedman School of Nutrition Science and Policy at Tufts. "Carriers of this gene variant appear to have more stable mechanisms for controlling their body weight," Ordovas says. "In people that have become obese, this leads to a blunting of the weight-loss effect we would expect to see with calorie restriction."

Andrew Greenberg, MD, director of the Obesity and Metabolism Laboratory at the USDA Center at Tufts, one of the scientists who discovered perilipin, notes that in an earlier study this same gene variant was linked with a lower risk of obesity, but in this study, it was associated with weight loss resistance.

"It may make sense," Greenberg says, "if we consider that this perilipin gene variant induces a sort of buffer against changes in how the body burns and stores food energy. It appears to protect against weight gain in lean women, while preventing weight loss in men and women who have become obese."

The clinical study was led by Dolores Corella, PhD, of the Genetic and Molecular Epidemiology Unit, University of Valencia, in Spain, who is a visiting scientist at the HNRCA and a long-term collaborator with Ordovas. These in
'"/>

Contact: Siobhan Gallagher
617-636-6586
Tufts University
7-Dec-2005


Page: 1 2

Related biology news :

1. Nutritional friend or foe? Vitamin E sends mixed messages
2. DOE Joint Genome Institute secures long-term lease on production genomics facility
3. Bronfman gift to Mount Sinai catalyzes genomics-based medicine
4. New science of metagenomics will transform modern microbiology
5. National Academies advisory: March 27 release of report on metagenomics
6. DOE JGI upgrades IMG/M -- the Metagenomics Data Management & Analysis System
7. National Science Foundation provides $14 million to advance research in comparative genomics
8. New study shows promise of toxicogenomics in environmental monitoring
9. Further investment for genomics announced
10. Berkeley Cancer Genome Center to study tumor genomics
11. Better sludge through metagenomics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/13/2019)... ... June 13, 2019 , ... Global Clinical and ... the end-to-end clinical and ancillary supply chain management needs of large- and middle-market ... organizations, today announced it will sponsor a summer education program offered by the ...
(Date:6/6/2019)... ... June 05, 2019 , ... MedTech Breakthrough , ... health and medical technology market, announced that it has selected Medacta International’s MySpine® ... award in the 2019 MedTech Breakthrough Awards program. , Medacta® ...
(Date:6/4/2019)... MEMPHIS, Tenn. (PRWEB) , ... June 04, 2019 ... ... in contract manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, ... the industry combined with successful roll-out of strategic investments & operational excellence initiatives ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... ... May 16, 2019 , ... ... a result, food and beverage products rely on these ingredients to create stable ... sounding label declarations. This paradigm shift triggers food formulators to seek out alternatives ...
(Date:5/8/2019)... ... ... Standing at 16.2 hands, Atlas is on the large side for a Quarter Horse. ... among other activities. When loping around a corner in late 2017, Atlas tripped and ... to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the opinion of ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the world ... Negative Response vision test, a new full field electroretinography (ffERG) protocol designed ... 6.3 million Americans will have glaucoma, with black Americans having the highest prevalence ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by leading ... free, so be sure to register today to save your place! Participate in the ... our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials – ...
Breaking Biology Technology:
Cached News: