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OHSU lab finds meth receptor that could lead to therapy

compounds that are being analyzed for their ability to selectively interfere with TAAR1 and block its activity.

"So we're already on a roll," Grandy said. The goal is to "take them to the point where they can be tested in humans."

Still, there's more to be learned about how meth and amphetamine affect the entire TAAR1 signaling system that is composed of six receptor genes in humans. "When you put it all together, what you realize is that meth acts on several signaling systems and that a successful therapeutic treatment will likely require modulation of several targets simultaneously. We still have a lot to learn about how meth affects the body through this system," Grandy said. "We have our work cut out for us."


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Contact: Jonathan Modie
modiej@ohsu.edu
503-494-8231
Oregon Health & Science University
18-Apr-2007


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