HOME >> BIOLOGY >> NEWS
OHSU scientists identify key gene that delays female puberty

SAN DIEGO Researchers at the OHSU Oregon National Primate Research Center (ONPRC) have identified a key gene that impacts the timing of puberty and can shorten the time span for reproduction. The research was led by Sergio Ojeda, Ph.D., head of the Division of Neuroscience and a senior scientist at ONPRC. The work will be presented at the Society for Neuroscience annual meeting on Oct 24, 2004 by Claudio Mastronardi, the lead author of the report.

"Using a mouse model, our lab has determined that the absence in the brain's hypothalamus of a gene called TTF-1 causes a delay in the onset of female puberty," explained Ojeda. "This work is of particular interest to those investigating both the delay and early onset of puberty in young women. While there is no definitive information, recently a number of research papers have been published suggesting that young women are reaching puberty at an earlier age. Other research has suggested that if this is the case, it may be linked to the nation's obesity crisis."

Prior to the research to be reported at the Society for Neuroscience meeting, Ojeda's group performed studies with rats showing that the TTF-1 gene is expressed in a discrete cellular subset of the hypothalamus during sexual development. Then, using a genome-wide approach, they determined that expression of the TTF-1 gene increases in the hypothalamus of nonhuman primates at the onset of puberty.

To conduct this latest research, Ojeda and his colleagues teamed up with Shioko Kimura, Ph.D., at the National Institute of Health's National Cancer Institute to study mice in which the TTF-1 gene had been deleted selectively from neurons. They then tracked development of these animals in comparison with a control group of wild-type littermate mice. The researchers found that animals lacking this gene exhibited delayed puberty. The mice lacking TTF-1 also had fewer litters, had fewer pups in each litter, and their reproductive time span was half
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-4158
Oregon Health & Science University
24-Oct-2004


Page: 1 2

Related biology news :

1. UK scientists working to help cut ID theft
2. Smithsonian scientists show differing patterns of rainforest biodiversity
3. Weizmann Institute scientists discover a control mechanism for metastasis
4. Cornell scientists link E. coli bacteria to Crohns disease
5. UCLA scientists produce functioning neurons from human embryonic stem cells
6. ASBMB taps 8 scientists and 1 politician for top awards
7. UF, French scientists seek test to detect gene doping in athletes
8. In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
9. Forsyth scientists gain new understanding of adult stem cell regulation
10. Nanotechnology helps scientists make bendy sensors for hydrogen vehicles
11. After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... KEY FINDINGS The global market ... CAGR of 25.76% during the forecast period of 2017-2025. ... for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is segmented ... The stem cell market of the product is segmented ...
(Date:3/30/2017)... , March 30, 2017  On April 6-7, 2017, ... the Genome hackathon at Microsoft,s headquarters in ... competition will focus on developing health and wellness apps ... Hack the Genome is the first hackathon ... The world,s largest companies in the genomics, tech and ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... 2017  VMS BioMarketing, a leading provider of patient support ... Nurse Educator (CNE) network, which will launch this week. The ... health care professionals to enhance the patient care experience by ... other health care professionals to help women who have been ... ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator ... osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular STAT3 ...
(Date:10/10/2017)... ... ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. spent ... entitled “Stem Cells and Their Regenerative Powers,” was held on August 31st, 2017 ... joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic Surgery, Grossmont ...
Breaking Biology Technology:
Cached News: