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Observational study suggests use of statins lowers risk of advanced prostate cancer

Anaheim, Calif. -- Use of such cholesterol-lowering drugs as statins may reduce the risk of advanced prostate cancer, according to research that followed 34,428 U.S. men for more than a decade.

The study, presented at the 96th Annual Meeting of the American Association for Cancer Research, found that men who used these medications had half the risk of advanced prostate cancer and a third of the risk of metastatic or fatal prostate cancer, compared to men who did not use cholesterol-lowering drugs. Risk of advanced prostate cancer fell with increasing duration of use of the drugs. The study did not find that use of cholesterol-lowering drugs had any influence on prostate cancer that is confined within the organ.

But while the researchers, from Johns Hopkins University, the National Cancer Institute and Harvard University, say that the magnitude of the inverse association between use of cholesterol-lowering drugs and advanced prostate cancer is impressive, they stress that confirmatory studies are needed.

"This is a very interesting and promising lead on a class of drugs that may be offering benefits that were not anticipated, but we need to replicate the findings in other large prospective studies as well as figure out the mechanisms at work," says lead investigator Elizabeth Platz, Sc.D., M.P.H., an assistant professor at the Johns Hopkins Bloomberg School of Public Health.

"If the conclusions continue to hold up over time, there is great translational potential for preventing invasive and metastatic prostate cancer," she says. The researchers believe most of the protective effect they observed comes from statins, rather than other types of cholesterol-lowering drugs, because by 2000 more than 90 percent of the men who reported that they were using cholesterol-lowering drugs said that they were using statins, in particular. The researchers also say they don't know whether the apparent benefit of statins is due to their cholesterol-l
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Contact: Warren R. Froelich
froelich@aacr.org
215-440-9300
American Association for Cancer Research
18-Apr-2005


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