HOME >> BIOLOGY >> NEWS
On target

In an upcoming Genes & Development paper, Dr. Christopher Counter and colleagues at the Duke University Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers.

Ras is a key intracellular messenger protein that directs, among other things, cell growth and proliferation. Over-expression of the Ras oncogene, or of its growth-promoting pathway, is an integral step in the development of a number of human cancers, particularly pancreatic and lung cancer. Unfortunately, though, attempts to target Ras for inhibition in a clinical setting have proved unsuccessful.

"We knew Ras was really important for cancer, but time after time it defied attempts to be inhibited in the clinic. So we decided, why not go after something that you can make a drug against that Ras activates"" explains Dr. Counter. Dr. Counter and colleagues sought to identify other proteins that are secreted when Ras is activated, and evaluate them as potential therapeutic candidates. One factor, in particular, is receiving a lot attention.

Interleukin-6 (IL6) is an inflammatory cytokine (growth factor) that stimulates the immune system in response to injury. Dr. Counters team has demonstrated that Ras induces the secretion of IL6 in a number of different cell types. The scientists then showed that IL6 promotes tumorigenesis by encouraging new blood vessel growth.

Dr. Counter and colleagues were able to successfully fight tumor formation in a preclinical model by suppressing IL6 activity. While further research is needed to determine the effectiveness of IL6 targeted cancer therapies, these initial results are encouraging. "Targeting secreted proteins that Ras activates has opened the door to inhibit the oncogenic signal of Ras via druggable proteins," states Dr. Counter


'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
14-Jul-2007


Page: 1

Related biology news :

1. Huntingtons disease study shows animal models on target
2. New target for HIV/AIDS drugs and vaccine discovered
3. When off-target is right on
4. Genomic analysis uncovers new targets for HIV vaccine
5. Bulls-eye -- Programs targeting math, science teacher shortage may get boost
6. Scientists take next step in understanding potential target for ovarian cancer treatment
7. New way to target and kill antibiotic-resistant bacteria found
8. Weill Cornell team identifies potential new cancer drug target
9. CSHL scientists successfully target tumor microenvironment to stop cancer growth
10. Sleep deprivation affects airport baggage screeners ability to detect rare targets
11. Genomic signatures identify targeted therapies for lung cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/13/2020)... , ... March 13, 2020 , ... ... new outbreak of coronavirus can cause conjunctivitis and possibly be transmitted by aerosol ... , Contact lens wearers should take special precautions to avoid contracting the ...
(Date:3/9/2020)... ... March 09, 2020 , ... ... last year, as enterprises sought to achieve competitive advantage by transforming their ... of all transformation efforts delivered the intended consequences. , Application transformation refers ...
(Date:3/5/2020)... ... 2020 , ... In September 2016, stem cell biotechnology company ... the first, and still only, available technology that provides the cell-specific count or ... about the number and quality of therapeutic tissue stem cells are unable to ...
Breaking Biology News(10 mins):
(Date:2/21/2020)... (PRWEB) , ... February 20, 2020 , ... ... ensuring supply chain transparency and reassuring consumers that what’s listed on an ingredient ... trademarked ingredients, Nutrition21 has introduced this solution with the adoption of CertainT, which ...
(Date:2/21/2020)... , ... February 21, 2020 , ... ... improve their manufacturing operations in order to adapt to new approaches like ‘Industry ... with the increasing demand for personalized medicine and therapies. But with an industry ...
(Date:2/19/2020)... ... 2020 , ... Intech , the leader in contract ... unified global brand identity, as it celebrates its 20th anniversary. , Fueled by ... an enthusiasm for designing and manufacturing state-of-the-art medical devices, Intech has grown leaps ...
(Date:2/13/2020)... ... 12, 2020 , ... Arriello , a provider of ... Veeva Vault Safety™ as part of the company’s continued growth in pharmacovigilance ... of safety information such as SUSARs and ICSRS, aggregate report production, signal management, ...
Breaking Biology Technology:
Cached News: