HOME >> BIOLOGY >> NEWS
One-dimensional diffusion accelerates molecular motors

Max Planck scientists have identified a new strategy which motor proteins use to move. The research was carried out by Prof. Jonathon Howard and Stefan Diez at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. The motor protein MCAK (Mitotic Centromere Associated Kinesin) goes into action at the end of microtubules where it disassembles them. This is in contrast to most other motor proteins, which transport materials over long distances along microtubules. The researchers were able to show that the protein reaches the position via a random, one-dimensional diffusion movement along the microtubule, until it locks into place at its end (Nature, May 4, 2006). This discovery is important for understanding cellular life processes like cell division and nerve cell growth.

When cells divide, they build a giant apparatus - the so called the "mitotic spindle". It is made up of microtubules; which are tiny protein polymers that can be built up and torn down like scaffolding. They also make up "tracks", along which motor proteins pull the halves of chromosomes into existing daughter cells. Until now, scientists have not known how the length of microtubule gets regulated, nor how the proteins reach the end of the microtubules to be regulated.

The Max Planck researchers looked at the example of the protein MCAK, and how it locates microtubule ends. Howard and his colleagues followed single MCAK molecules under the microscope and could see that MCAK docks randomly anywhere on a microtubule, and then slides around on its surface.

This "random" strategy is surprisingly efficient and successful. It allows MCAK to localize microtubule ends very quickly. Howard says, "when it gets there, MCAK eats like a Pacman into the end of the microtubule." The chromosome halves follow this movement and are this way accurately distributed on the daughter cells.


'"/>

Contact: Prof. Jonathon Howard
howard@mpi-cbg.de
0049-351-210-2500
Max-Planck-Gesellschaft
12-May-2006


Page: 1

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Gene therapy accelerates healing of damaged skeletal muscle
3. Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
4. Chronic stress accelerates atherosclerosis following angioplasty procedure
5. Gene loss accelerates aging
6. Redesigned protein accelerates blood clotting
7. Study to determine if air pollution accelerates development of cardiovascular disease
8. $3 million donation accelerates TGen breast cancer research
9. Excess dietary fat accelerates breast cancer by altering the activity of a group of genes
10. New textbook illuminates the close links between evolutionary and molecular biology
11. New molecular regulators of hyperthyroidism and goiter

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One dimensional diffusion accelerates molecular motors

(Date:10/19/2014)... the last 30 years contributed only marginally to ... time, according to a new study published in ... access is fundamental to development: it brings improvements ... and health," says IIASA researcher Shonali Pachauri, who ... is widely agreed to be an important goal ...
(Date:10/17/2014)... German . ... in order to reproduce? And why are there two sexes ... latest issue of the research journal Molecular Human Reproduction ... Ramm from Bielefeld University Bielefeld has compiled this special issue ... a female to copulate with several males in quick succession ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
Breaking Biology News(10 mins):Improved electricity access has little impact on climate change 2Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2
(Date:10/22/2014)... According to new market research report ... Integration, Deployment & Support), by Service Model (SaaS, ... Others (Hybrid & Community)) - Global Forecast to ... Cloud Professional Services Market into various sub-segments with ... also identifies the drivers and restraints for this ...
(Date:10/22/2014)... Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... next steps for its Oral Amphotericin B program.  ... in vitro work involving samples from ... plans to complete pre clinical studies and regulatory ... 1A clinical trial, utilizing approximately $700,000 of funding ...
(Date:10/22/2014)... , Oct. 22, 2014 Research and ... Electronics Market by Material, by Application, Geography - Global ... their offering. Organic electronics, also called ... of material science which deals with small conductive molecules ... because small molecules and polymers are carbon based, made ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market ... Labeling Systems, Table-top Counters) by End-user (Inpatient Pharmacy ... Trends to 2019” analyzes and studies the major ... Europe, Asia-Pacific, and the Rest of the World ... figures spread through 300 pages and in-depth TOC ...
Breaking Biology Technology:Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
Cached News: