HOME >> BIOLOGY >> NEWS
One-dimensional diffusion accelerates molecular motors

Max Planck scientists have identified a new strategy which motor proteins use to move. The research was carried out by Prof. Jonathon Howard and Stefan Diez at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. The motor protein MCAK (Mitotic Centromere Associated Kinesin) goes into action at the end of microtubules where it disassembles them. This is in contrast to most other motor proteins, which transport materials over long distances along microtubules. The researchers were able to show that the protein reaches the position via a random, one-dimensional diffusion movement along the microtubule, until it locks into place at its end (Nature, May 4, 2006). This discovery is important for understanding cellular life processes like cell division and nerve cell growth.

When cells divide, they build a giant apparatus - the so called the "mitotic spindle". It is made up of microtubules; which are tiny protein polymers that can be built up and torn down like scaffolding. They also make up "tracks", along which motor proteins pull the halves of chromosomes into existing daughter cells. Until now, scientists have not known how the length of microtubule gets regulated, nor how the proteins reach the end of the microtubules to be regulated.

The Max Planck researchers looked at the example of the protein MCAK, and how it locates microtubule ends. Howard and his colleagues followed single MCAK molecules under the microscope and could see that MCAK docks randomly anywhere on a microtubule, and then slides around on its surface.

This "random" strategy is surprisingly efficient and successful. It allows MCAK to localize microtubule ends very quickly. Howard says, "when it gets there, MCAK eats like a Pacman into the end of the microtubule." The chromosome halves follow this movement and are this way accurately distributed on the daughter cells.


'"/>

Contact: Prof. Jonathon Howard
howard@mpi-cbg.de
0049-351-210-2500
Max-Planck-Gesellschaft
12-May-2006


Page: 1

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Gene therapy accelerates healing of damaged skeletal muscle
3. Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
4. Chronic stress accelerates atherosclerosis following angioplasty procedure
5. Gene loss accelerates aging
6. Redesigned protein accelerates blood clotting
7. Study to determine if air pollution accelerates development of cardiovascular disease
8. $3 million donation accelerates TGen breast cancer research
9. Excess dietary fat accelerates breast cancer by altering the activity of a group of genes
10. New textbook illuminates the close links between evolutionary and molecular biology
11. New molecular regulators of hyperthyroidism and goiter

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: One dimensional diffusion accelerates molecular motors

(Date:10/15/2014)... of Life, is a non-traditional biophysics textbook and it ... is a journey of discovery into biological systems and ... biological regulation. It is about how our genes make ... the billions of cells in an organism. It quantifies ... principles, which can be found on both large and ...
(Date:10/15/2014)... Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market releases photos and video ... Square on Monday October 13 th . ... Tunnel and angel investor Mr. Chad A. Verdi ... of NXT-ID thanked his investors and employees "for their work and ...
(Date:10/14/2014)... Cancer Research shows SIRT6—a protein known to ... the development of skin cancers by turning on an ... skin cells. , Previously considered protective, SIRT6 is part ... help regulate genomic stability and prevent some of the ... damage, which can lead to cancer. This study, in ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/22/2014)... 22, 2014 Physicians Choice Laboratory ... pharmacogenetics menu, which enables healthcare providers to individualize ... PCLS’s evidence-based results, healthcare providers are better able ... therapy, while minimizing risks for adverse drug reactions ... to the FDA [1] more than 2.2 million ...
(Date:10/22/2014)... 2014 Research and Markets  has announced ... Material, by Application, Geography - Global Analysis and Forecast ... Organic electronics, also called as polymer electronics ... which deals with small conductive molecules and electrically conductive ... and polymers are carbon based, made using synthetic strategies ...
(Date:10/20/2014)... , Oct. 20, 2014 Asterias ... the Company has signed a Notice of Grant ... Medicine (CIRM), effective October 1, 2014.  The NGA ... payments and the release of additional grant funds ... grant award for clinical development of Asterias, product, ...
(Date:10/20/2014)... N.J. (PRWEB) October 20, 2014 ... the Sidney Kimmel Cancer Center at Thomas Jefferson ... , Through the Strategic Alliance Partnership program, ... OncLive will collaborate to raise awareness of the ... treatment, and other projects. Clinicians and other health ...
Breaking Biology Technology:PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 2PCLS Announces Expansion of Cardiovascular Pharmacogenetic Testing Menu 3Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 2Global Organic Electronics (Semiconductor, Conductive, Dielectric and Substrate) Market - Analysis and Forecast (2014 - 2020) 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 2Sidney Kimmel Cancer Center at Thomas Jefferson University Partners With OncLive 3
Cached News: