HOME >> BIOLOGY >> NEWS
One-dimensional diffusion accelerates molecular motors

Max Planck scientists have identified a new strategy which motor proteins use to move. The research was carried out by Prof. Jonathon Howard and Stefan Diez at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden. The motor protein MCAK (Mitotic Centromere Associated Kinesin) goes into action at the end of microtubules where it disassembles them. This is in contrast to most other motor proteins, which transport materials over long distances along microtubules. The researchers were able to show that the protein reaches the position via a random, one-dimensional diffusion movement along the microtubule, until it locks into place at its end (Nature, May 4, 2006). This discovery is important for understanding cellular life processes like cell division and nerve cell growth.

When cells divide, they build a giant apparatus - the so called the "mitotic spindle". It is made up of microtubules; which are tiny protein polymers that can be built up and torn down like scaffolding. They also make up "tracks", along which motor proteins pull the halves of chromosomes into existing daughter cells. Until now, scientists have not known how the length of microtubule gets regulated, nor how the proteins reach the end of the microtubules to be regulated.

The Max Planck researchers looked at the example of the protein MCAK, and how it locates microtubule ends. Howard and his colleagues followed single MCAK molecules under the microscope and could see that MCAK docks randomly anywhere on a microtubule, and then slides around on its surface.

This "random" strategy is surprisingly efficient and successful. It allows MCAK to localize microtubule ends very quickly. Howard says, "when it gets there, MCAK eats like a Pacman into the end of the microtubule." The chromosome halves follow this movement and are this way accurately distributed on the daughter cells.


'"/>

Contact: Prof. Jonathon Howard
howard@mpi-cbg.de
0049-351-210-2500
Max-Planck-Gesellschaft
12-May-2006


Page: 1

Related biology news :

1. Scripps research scientists show protein accelerates breast cancer progression in animal models
2. Gene therapy accelerates healing of damaged skeletal muscle
3. Georgia Tech accelerates drug discovery with new IBM supercomputing cluster
4. Chronic stress accelerates atherosclerosis following angioplasty procedure
5. Gene loss accelerates aging
6. Redesigned protein accelerates blood clotting
7. Study to determine if air pollution accelerates development of cardiovascular disease
8. $3 million donation accelerates TGen breast cancer research
9. Excess dietary fat accelerates breast cancer by altering the activity of a group of genes
10. New textbook illuminates the close links between evolutionary and molecular biology
11. New molecular regulators of hyperthyroidism and goiter

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... Research and Markets has announced the addition of the "Global ... ... at a CAGR of 30.37% during the period 2017-2021. ... based on an in-depth market analysis with inputs from industry experts. ... the coming years. The report also includes a discussion of the ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... Throughout this webinar, participants ... how process development and economic goals were achieved in both industry and academic ... bioreactor system, along with techniques for scaling production of mesenchymal stem cells (MSCs) ...
(Date:5/24/2017)... ... May 24, 2017 , ... Benchworks announced that ... of the Healthcare Businesswomen’s Association (HBA). Nominated by chapter president Donna ... meets in person once each quarter and holds monthly conference calls. In addition, ...
(Date:5/24/2017)... ... 23, 2017 , ... Federal funding for basic and applied scientific research — ... and other vital technologies — deserves continued support, say leaders of SPIE, the ... today in responding to the President’s budget request for Fiscal Year 2018. , The ...
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex today ... makes it easy for organizations to send and gather large files and confidential ... or email file size limitations. , Using the same market-tested infrastructure as ...
Breaking Biology Technology:
Cached News: