HOME >> BIOLOGY >> NEWS
One gene links newborn neurons with those that die in diseases such as Alzheimer's

In certain parts of the brain, cells called neurons go through a cycle of death and replenishment. New research from Rockefeller University's Fernando Nottebohm, Ph.D., shows that these replaceable neurons share something in common with the neurons that die in people with diseases such as Alzheimer's and Parkinson's: both have unusually low levels of a protein called UCHL1.

"It would be ironic if the shortfall in a same gene brokered the path to brain disease or rejuvenation," says Nottebohm, who is Dorothea Leonhardt Professor and head of the Laboratory of Animal Behavior. "But naturally replaced neurons may hold the key to understanding processes of neurodegeneration."

The results appear in the May 23 Early Edition issue of Proceedings of the National Academy of Sciences.

The potential medical implications of the study came as a surprise to the researchers. They set out to answer fundamental questions about the small number of brain neurons that can be replaced when they die: Are these cells similar to other neurons that are not replaced in adult life? Or, in terms of which genes are "turned on," are they marked as transient?

Nottebohm's laboratory has pioneered the study of the brain pathways controlling how songbirds learn to sing. A discrete region of the brains of songbirds, known as the high vocal center, controls their singing behavior. It was in this brain region that, more than 20 years ago, Nottebohm discovered new neurons being born in adult birds, overturning the conventional wisdom that all neurons in vertebrates are created by birth or soon after.

In the new study, the researchers looked at cells in the high vocal center region of the brains of 19 zebra finches, a kind of songbird native to Australia that has long been used in studies of birdsong. Since replaceable neurons sit side-by-side with neurons that are not replaced, the first step was to label the two kinds of cells in order to tell them apart.


'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
23-May-2005


Page: 1 2 3 4

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Preclinical study links gene to brain aneurysm formation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. New mechanism links smoking to lung damage
5. UCLA study links air pollution to clogged arteries
6. University of Leeds strengthens China links in membrane and neurobiology
7. Satellite survey links tropical park fires with poverty and corruption
8. Genetic defect links respiratory disease and congenital heart disease
9. West African Ocean sediment core links monsoons to global climate evolution
10. CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
11. Salk researchers discover first gene that specifically links calorie restriction to longevity

Post Your Comments:
(Date:7/23/2014)... songbirds are disappearing, and though conservationists are examining several ... acid rain and light pollution, a key piece of ... go once they leave their breeding sites, and what ... To answer this question, a team of researchers out ... connectivity map produced for a songbird, using tracking from ...
(Date:7/23/2014)... have no access to clean drinking water. According to ... from water-related diseases every year. ETH student Jeremy Nussbaumer ... solving this problem. Working with researchers from a group ... Laboratory, the 23-year-old spent a year researching a membrane ... DrinkPure filter unique is that you can screw it ...
(Date:7/23/2014)... This news release is available in German . ... shape and stability to cells, drive metabolic processes and ... into complex three-dimensional shapes. Scientists at the Max Planck ... that proteins can be constructed of similar amino acid ... suggests that the proteins that exist today arose from ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2ETH student develops filter for clean water around the world 2Protein evolution follows a modular principle 2
(Date:7/22/2014)... water with ultrasound and they,ll spin around their long ... knows exactly. But researchers at the National Institute of ... fast. At up to 150,000 revolutions per minute, these ... submerged in liquid ever reported. , The discovery of ... they could be used not only for moving around ...
(Date:7/22/2014)... DALLAS , July 22, 2014   ... replacement therapy using natural, bio-identical hormone pellets, today ... , MD to the company.   Dr. Rouzier is ... training physician.      Dr. Rouzier was ... at UCLA and is a board certified emergency ...
(Date:7/22/2014)... Alachua, Fla. (PRWEB) July 22, 2014 ... cyclodextrins for the pharmaceutical, medical device, cosmetics, and other ... Private Placement with a group of qualified private investors ... Pharmacia. , The transaction involved the ... Holdings issued 1,725,000 shares of Common Stock at a ...
(Date:7/22/2014)... Lake, Wisconsin (PRWEB) July 22, 2014 ... be in attendance at the 2014 NCSL International ... Booth #423 will feature CONDEC pressure instrumentation, ... style weights, and the new, customized sets, Essential ... ago to promote cooperative efforts in solving the ...
Breaking Biology Technology:NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2Dr. Neal Rouzier Joins BioTE Medical 2Dr. Neal Rouzier Joins BioTE Medical 3CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Rice Lake Weighing Systems Showcases Metrology Solutions for the 2014 NCSL International Workshop & Symposium 2
Cached News: