HOME >> BIOLOGY >> NEWS
One gene links newborn neurons with those that die in diseases such as Alzheimer's

In certain parts of the brain, cells called neurons go through a cycle of death and replenishment. New research from Rockefeller University's Fernando Nottebohm, Ph.D., shows that these replaceable neurons share something in common with the neurons that die in people with diseases such as Alzheimer's and Parkinson's: both have unusually low levels of a protein called UCHL1.

"It would be ironic if the shortfall in a same gene brokered the path to brain disease or rejuvenation," says Nottebohm, who is Dorothea Leonhardt Professor and head of the Laboratory of Animal Behavior. "But naturally replaced neurons may hold the key to understanding processes of neurodegeneration."

The results appear in the May 23 Early Edition issue of Proceedings of the National Academy of Sciences.

The potential medical implications of the study came as a surprise to the researchers. They set out to answer fundamental questions about the small number of brain neurons that can be replaced when they die: Are these cells similar to other neurons that are not replaced in adult life? Or, in terms of which genes are "turned on," are they marked as transient?

Nottebohm's laboratory has pioneered the study of the brain pathways controlling how songbirds learn to sing. A discrete region of the brains of songbirds, known as the high vocal center, controls their singing behavior. It was in this brain region that, more than 20 years ago, Nottebohm discovered new neurons being born in adult birds, overturning the conventional wisdom that all neurons in vertebrates are created by birth or soon after.

In the new study, the researchers looked at cells in the high vocal center region of the brains of 19 zebra finches, a kind of songbird native to Australia that has long been used in studies of birdsong. Since replaceable neurons sit side-by-side with neurons that are not replaced, the first step was to label the two kinds of cells in order to tell them apart.


'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
23-May-2005


Page: 1 2 3 4

Related biology news :

1. New textbook illuminates the close links between evolutionary and molecular biology
2. Preclinical study links gene to brain aneurysm formation
3. UCF research links proteins, stem cells and potential Alzheimers treatment
4. New mechanism links smoking to lung damage
5. UCLA study links air pollution to clogged arteries
6. University of Leeds strengthens China links in membrane and neurobiology
7. Satellite survey links tropical park fires with poverty and corruption
8. Genetic defect links respiratory disease and congenital heart disease
9. West African Ocean sediment core links monsoons to global climate evolution
10. CSHL links activity in brain synapses and developmental abnormalities with schizophrenia gene
11. Salk researchers discover first gene that specifically links calorie restriction to longevity

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/6/2017)... Colo. , Jan. 5, 2017  SomaLogic ... the "Digital Life Alliance" established by iCarbonX, the ... 2015 to build a "Global Digital Health Ecosystem ... on a combination of individual,s biological, behavioral and ... the agreement between the companies, SomaLogic will provide ...
(Date:12/22/2016)... , Dec. 20, 2016  As part of its longstanding ... leading personal genetics company, recently released its latest children,s book, ... The book focuses on the topics of inheritance and variation ... Standards (NGSS) taught in elementary school classrooms in the US. ... series by illustrator Ariana Killoran , whose previous book ...
(Date:12/16/2016)... 2016   IdentyTechSolutions America LLC , a ... solutions and a cutting-edge manufacturer of software and ... offering seamless, integrated solutions that comprise IDT biometric ... solutions provide IdentyTech,s customers with combined physical identification ... crime and theft. "We are proud ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... ... January 17, 2017 , ... Pono Ola , ... and healthy lifestyle, announced today the official launch of its much-anticipated Pono Board: a ... , In development for over a year, the patented Pono Board is ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... epigenetics research, recently announced a collaboration with the Heidelberg University Hospital and the ... for library preparation, following the company’s successful launch of its CATS (Capture ...
(Date:1/16/2017)... , ... January 16, 2017 , ... ... laws precedential publication its decision on the appeal filed by India-based Dishman Pharmaceutical ... breach of contract against DPCL and one of its Dishman Group’s 100% wholly ...
(Date:1/16/2017)... LOUISVILLE, Ky. , Jan. 16, 2017  Eurofins ... service, which will allow more customers to receive their ... price premium or compromise in quality found with other ... the United States at no additional ... variety of routine genetic studies, including DNA sequencing, genotyping, ...
Breaking Biology Technology:
Cached News: