Other highlights from the April 18 Journal of the National Cancer Institute

New Culture Technique Could Lead to Drug Discoveries

A novel cell culture technique for a noninvasive breast malignancy known as ductal carcinoma in situ (DCIS) could facilitate the discovery of new drugs to prevent DCIS recurrence or progression.

Gillian Farnie, Ph.D, of the University of Manchester in England, and colleagues developed a novel method to culture DCIS cells, and using this method, they examined the role of the epidermal growth factor receptor and Notch signaling pathways in the growth of DCIS. They found that both pathways were involved in self-renewal of DCIS cells; the former was necessary for DCIS growth, and the latter was important for cell survival.

"To our knowledge, no culture technique for DCIS exists; thus, the nonadherent culture technique that we describe should be useful for isolating tumor-forming epithelial cells from their primary DCIS lesions to allow a better understanding of their growth," the authors write.

Contact: Gillian Farnie, Ph.D, of the University of Manchester, 0161 446 3212, Gillian.Farnie@manchester.ac.uk

Shortened HER2 Gene Responds to Lapatinib, Not Trastuzumab

Breast cancer cells expressing a shortened form of the HER2 gene can be treated with lapatinib, but they are resistant to another drug known as trastuzumab.

HER2 is a gene in the epidermal growth factor receptor family that plays a role in regulating cell growth. In about 15 to 20 percent of breast cancers, HER2 is overexpressed, and women with these kinds of tumors have a worse than average prognosis. Many breast cancers that express HER2 are resistant to the HER2 antibody trastuzumab, a drug often used to treat HER2-positive breast cancer. Some are resistant because they express p95HER2, a shortened form of the receptor that cannot bind to trastuzumab.

Maurizio Scaltriti, of the Vall d'He

Contact: Liz Savage
Journal of the National Cancer Institute

Page: 1 2

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the March 21 JNCI
9. Other highlights in the March 7 JNCI
10. Other highlights in the Feb. 21 JNCI
11. Other highlights in the Jan. 17 JNCI

Post Your Comments:

(Date:7/1/2020)... ... July 01, 2020 , ... Cure Glioblastoma, a ... most common and aggressive adult brain cancer—announced today the appointments of its first ... charged with supporting the organization’s initiatives and overall vision. , "Senior Fellows are ...
(Date:6/23/2020)... ... June 23, 2020 , ... First Aid Africa, a Scottish ... supplier and manufacturer of innovative portable renewable energy equipment, have announced the success ... the COVID-19 pandemic in Zambia. , One of Renovagen’s FAST FOLD portable solar ...
(Date:6/19/2020)... SAN DIEGO (PRWEB) , ... ... ... host a three-part webinar series, “Automate Your Lab with Software for Data ... engineers. Attendees will learn how to integrate and automate cutting-edge scientific instruments ...
Breaking Biology News(10 mins):
(Date:7/31/2020)... ... July 29, 2020 , ... ... radar transmitter systems that can be configured to drive Klystrons, TWTs, IOTs, and ... can drive one or two switches in a push-pull configuration; yielding fast fall ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
(Date:7/18/2020)... ... ... “We are thrilled to deliver this new technology to the industry” said Matt Hundt, ... market and we were pleased that the IFT jury recognized that.” reFRESH™ couples the ... natural way to extend the shelf life and improve the safety of perishable foods ...
(Date:7/10/2020)... (PRWEB) , ... July 09, ... ... biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has expanded ... broader license allows PathSensors to move into the point-of-care diagnostic market, focusing ...
Breaking Biology Technology:
Cached News: