HOME >> BIOLOGY >> NEWS
Other highlights from the July 10 JNCI

Nanobubbles Deliver Targeted Cancer Drugs Using Ultrasound

A new targeted drug delivery method uses ultrasound to image tumors, while also releasing the drug from nanobubbles into the tumor.

Cancer drugs can be targeted to tumors by delivering them in packets of nanoparticles, then releasing them with ultrasound. But this approach can be difficult because it requires a way to image the tumor prior to treatment.

Natalya Rapoport, Ph.D., D.Sc., of the University of Utah in Salt Lake City and colleagues describe a new method of drug delivery that may address this problem. Nanobubbles filled with the chemotherapy drug doxorubicin were injected into mice. The bubbles accumulated in the tumors, where they combined to form larger microbubbles. When exposed to ultrasound, the bubbles generated echoes, which made it possible to image the tumor. The sound energy from the ultrasound popped the bubbles, releasing the drug. In mice treated with this method, the nanobubbles were more effective at blocking tumor growth than other nanoparticle delivery methods.

Microbubble formulations have been developed for combining ultrasonic tumor imaging and ultrasound-enhanced chemotherapeutic treatment, the authors write.

Contact: Natalya Rapoport, natasha.rapoport@m.cc.utah.edu, (801) 581-8990


Gene May Promote Resistance to Chemotherapy Drugs

A gene known as HDAC1 may be a good target for drugs to treat multidrug-resistant neuroblastoma, a cancer that develops in immature nerve cells and is prevalent in children.

Drug resistance could explain why about 50% of high-risk neuroblastoma patients die of the disease. Nino Keshelava, M.D., of Childrens Hospital Los Angeles and colleagues studied several human neuroblastoma cell lines to identify genes that cause drug resistance.

They found that HDAC1 was overexpressed in m
'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
10-Jul-2007


Page: 1 2

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights in JNCI, June 26
4. Other highlights in JNCI, June 12
5. Other highlights from the June 6 JNCI
6. Other highlights in the May 16 JNCI
7. Other highlights from the April 18 Journal of the National Cancer Institute
8. Other highlights from the March 21 JNCI
9. Other highlights in the March 7 JNCI
10. Other highlights in the Feb. 21 JNCI
11. Other highlights in the Jan. 17 JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2020)... (PRWEB) , ... August 20, 2020 , ... ... that Hassan Movahhed , a Clinical Operations executive with expertise in clinical ... has joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed ...
(Date:8/12/2020)... ... August 12, 2020 , ... Mosio recently ... ideal for public health agencies of all sizes. With a focus on tracking ... individuals find appropriate health care, Mosio helps public health departments automate communications and ...
(Date:8/7/2020)... ... August 06, 2020 , ... Nine middle school teachers ... Scholar Program, a unique professional development program that provides advanced STEM (science, technology, ... science teachers nationwide. , Created in partnership between the National Stem Cell Foundation ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... HOUSTON (PRWEB) , ... August ... ... a biopharmaceutical cold chain validation engineering firm, is making available for ... driving the need to incorporate concurrent transport simulation testing into today’s biologics ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... Jim Corrigan, President and CEO has been named one of the 100 most ... industry sectors, PharmaVoice 100 honorees are selected based on how they have inspired ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... Catalent, the leading global provider of advanced delivery technologies, development, and manufacturing solutions ... that they have entered into a strategic partnership whereby Catalent will provide support ...
Breaking Biology Technology:
Cached News: