Other highlights from the June 6 JNCI

the material surrounding the cells, known as extracellular matrix.

Baoguo Ren, M.D., of the University of Pittsburgh, and colleagues identified integrin 7 mutations in specimens from several different types of cancers, and four cell lines.

Mutations were found in 16 of 28 prostate cancer samples, 8 of 24 liver cancer samples, 5 of 6 glioblastoma samples, and 1 of 4 leiomyosarcomas (cancer of smooth muscle cells). When integrin 7 expression in prostate cancer and leiomyosarcoma cell lines was restored to normal levels, tumors generated from these cells grew more slowly and produced fewer metastates.

The ubiquitous expression of integrin 7 in human organs and widespread mutations of this gene in human cancers raise the possibility that integrin 7 may have a role in the development of many human malignancies, the authors write.

Contact: Jim Swyers, University of Pittsburgh, swyersjp@upmc.edu, (412) 586-9773

Inflammation Protein Is Not Associated With Breast Cancer Risk

C-reactive protein (CRP), a marker of inflammation, is not associated with breast cancer risk among healthy women, despite earlier studies that suggest a link between chronic inflammation to breast cancer development.

Using data from the Womens Health Study, Shumin Zhang, M.D., Sc.D., of Brigham and Womens Hospital in Boston, and colleagues evaluated whether levels of CRP were associated with future breast cancer risk. After an average of 10 years of follow-up, the researchers found no association.

In patients who are diagnosed with breast cancer, elevated levels of CRP or interleukin-6 are associated with reduced survival, suggesting that CRP levels may rise after the onset of breast cancer and be a prognostic indicator for survival in patients. However, data are sparse regarding whether or not CRP is associated with breast cancer risk among apparently healthy women

Contact: Liz Savage
Journal of the National Cancer Institute

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1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights in the May 16 JNCI
7. Other highlights from the April 18 Journal of the National Cancer Institute
8. Other highlights from the March 21 JNCI
9. Other highlights in the March 7 JNCI
10. Other highlights in the Feb. 21 JNCI
11. Other highlights in the Jan. 17 JNCI

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