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Other highlights from the June 6 JNCI

the material surrounding the cells, known as extracellular matrix.

Baoguo Ren, M.D., of the University of Pittsburgh, and colleagues identified integrin 7 mutations in specimens from several different types of cancers, and four cell lines.

Mutations were found in 16 of 28 prostate cancer samples, 8 of 24 liver cancer samples, 5 of 6 glioblastoma samples, and 1 of 4 leiomyosarcomas (cancer of smooth muscle cells). When integrin 7 expression in prostate cancer and leiomyosarcoma cell lines was restored to normal levels, tumors generated from these cells grew more slowly and produced fewer metastates.

The ubiquitous expression of integrin 7 in human organs and widespread mutations of this gene in human cancers raise the possibility that integrin 7 may have a role in the development of many human malignancies, the authors write.

Contact: Jim Swyers, University of Pittsburgh, swyersjp@upmc.edu, (412) 586-9773


Inflammation Protein Is Not Associated With Breast Cancer Risk

C-reactive protein (CRP), a marker of inflammation, is not associated with breast cancer risk among healthy women, despite earlier studies that suggest a link between chronic inflammation to breast cancer development.

Using data from the Womens Health Study, Shumin Zhang, M.D., Sc.D., of Brigham and Womens Hospital in Boston, and colleagues evaluated whether levels of CRP were associated with future breast cancer risk. After an average of 10 years of follow-up, the researchers found no association.

In patients who are diagnosed with breast cancer, elevated levels of CRP or interleukin-6 are associated with reduced survival, suggesting that CRP levels may rise after the onset of breast cancer and be a prognostic indicator for survival in patients. However, data are sparse regarding whether or not CRP is associated with breast cancer risk among apparently healthy women
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Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1285
Journal of the National Cancer Institute
5-Jun-2007


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