HOME >> BIOLOGY >> NEWS
Other highlights from the March 21 JNCI

lsall foods rich in lignansshould continue," the authors write.

Contact: Dr.Francoise Clavel-Chapelon, National Institute of Health and Medical Research, +33 142114148, clavel@igr.fr


Outcome of Progression-Free Survival May Result in Biased Trial Results

Measurement of progression-free survival, a widely used endpoint in cancer clinical trials, has methodological flaws that can lead to biased estimates.

Katherine Panageas, Dr.P.H., of Memorial Sloan-Kettering Cancer Center in New York, and colleagues examined the use of progression-free survival (PFS) as an endpoint measurement in clinical trials.

PFS is measured as the time from start of treatment to the first measurement of cancer growth. Disease progression is typically measured by radiologic tests, such as x-rays, at scheduled intervals. Most often, researchers do not know when progression actually occurs, so they can only estimate that it happened sometime between the test that showed progression and the previous one.

Methodological problems can arise when researchers define the date of progression as the date on which it was first detected, even though progression most likely occurred prior to that day. The researchers compared a variety of surveillance intervals using a simulated population to demonstrate how the evaluation schedule can affect the estimation of PFS.

The researchers found that the outcome of the trial can be heavily influenced by the surveillance interval and that comparing the PFS times of two studies with different evaluation schedules can lead to erroneous conclusions.

"The decision to use PFS as a primary endpoint should be considered carefully in the design phase of the trial. It is our intention to make researchers aware that estimates of PFS are highly dependent on when they look for progression. The clinical research community can address this co
'"/>

Contact: Liz Savage
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
20-Mar-2007


Page: 1 2 3 4

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights in the March 7 JNCI
10. Other highlights in the Feb. 21 JNCI
11. Other highlights in the Jan. 17 JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/30/2020)... ... April 28, 2020 , ... Pebble Labs USA Inc. , a ... and aquaculture with the mission of improving global food security, announced today that they ... Next Heroes in Food- and Ag-Tech ' virtual event, a global initiative to drive ...
(Date:4/26/2020)... ... April 23, 2020 , ... ... miniaturization, backed by FII Tech Growth managed by Fondo Italiano d’Investimento SGR, today ... market, for the development of Respira, a new non-invasive pulmonary ventilator created in ...
(Date:4/22/2020)... , ... April 21, 2020 , ... ... a patent leveraged venture capital firm that provides patent development support for early ... detect and treat illnesses such as ovarian cancer and precancerous pancreatic lesions with ...
Breaking Biology News(10 mins):
(Date:5/5/2020)... , ... May 05, 2020 , ... ProductLife Group ... high-profile CEO. Xavier Duburcq joins the group after 13 years at Altran, where he ... Holding a PhD in Immunology and being a Pharmacist, Xavier was involved in his ...
(Date:4/26/2020)... YORK (PRWEB) , ... April 23, 2020 , ... ... the Azure Marketplace today, an online store providing applications and services for use ... with certain well-defined business needs to sign up online for a built-for-purpose customer ...
(Date:4/22/2020)... ... April 21, 2020 , ... Aniara Diagnostica is pleased ... , Aniara Diagnostica, a multi-national distributor of diagnostic and research agents, as well ... product quality and cost-efficient delivery. , For Research Use Only. Not ...
(Date:4/7/2020)... JOLLA, Calif. (PRWEB) , ... April 06, 2020 , ... ... into their future children, reached 200,000 SneakPeek Early Gender DNA Tests sold ... “ SneakPeek was launched as an ecommerce product, where a mom could order ...
Breaking Biology Technology:
Cached News: