Other highlights in JNCI, June 26

researchers found that eight other endpoints were used in addition to overall survival. Moreover, the definitions of these endpoints varied widely among studies.

A panel of clinical trial experts reached a consensus on definitions for the endpoints and determined if and when they should be used in future trials. Six of the endpoints were selected as relevant to treatment trials: disease-free survival, time to recurrence, time to treatment failure, relapse-free survival, cancer-specific survival, and overall survival.

After considering all six endpoints, the panel selected disease-free survivalas the most appropriate primary endpoint for future trials of adjuvant treatment for colon cancer or for any type of cancer. This endpoint was selected because it includes all clinically relevant events, has little opportunity for bias, is observed earlier than overall survival, and is likely to be statistically sensitive to real treatment benefits, the authors write.

Contact: Cornelis Punt, +31243610353, c.punt@onco.umcn.nl

New Trial Design May Better Test Targeted Therapies

A new design for phase III trials will allow researchers to more efficiently evaluate the effectiveness of targeted therapies.

Many cancer drugs that target specific molecules only benefit a subset of patients who have high enough levels of the target molecule. Often, though, phase III clinical trials are designed without knowledge of this threshold, so the trial includes patients who will not respond to the treatment. That means the drugs effect on the group of responsive patients could be missed.

Wenyu Jiang, Ph.D., of the National Cancer Institute in Bethesda, Md., and colleagues propose a different trial design that combines the usual test for response to treatment in all patients with the identification and validation of a cutoff point for a molecular target. They teste

Contact: Liz Savage
Journal of the National Cancer Institute

Page: 1 2 3

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 12
5. Other highlights from the June 6 JNCI
6. Other highlights in the May 16 JNCI
7. Other highlights from the April 18 Journal of the National Cancer Institute
8. Other highlights from the March 21 JNCI
9. Other highlights in the March 7 JNCI
10. Other highlights in the Feb. 21 JNCI
11. Other highlights in the Jan. 17 JNCI

Post Your Comments:

(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: