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Other highlights in the April 20 JNCI

Study of Atomic Bomb Survivors Finds Association Between Radiation Exposure and Male Breast Cancer

Exposure to ionizing radiation is associated with an increased risk of male breast cancer, according to a new study.

Male breast cancer is rare, accounting for less than 0.5% of cancers in males and about 1% of all breast cancers. Because of its rarity, the etiology of the disease has not been well described, but many of the risk factors for breast cancer in women--including family history and higher social class--are known to be risk factors for breast cancer in men as well. However, it is not known if ionizing radiation, a well-known risk factor for female breast cancer, is also a risk factor for male breast cancer.

To investigate the role of ionizing radiation in the development of male breast cancer, Elaine Ron, Ph.D., of the National Cancer Institute, and colleagues evaluated male breast cancer incidence among the 45,880 male members of the Life Span Study cohort of Japanese atomic bomb survivors.

There were nine cases of male breast cancer among exposed study members (1.8 cases per 100,000 person years), and three cases among non-exposed study members (0.5 cases per 100,000 person years). The researchers conclude that these results add to the limited information that has shown an association between ionizing radiation and male breast cancer risk.

Contact: National Cancer Institute Press Office, 301-496-6641, NCIPressOfficers@mail.nih.gov

Study Examines Natural History of HPV in HIVPositive Women

Women with human immunodeficiency virus (HIV)/AIDS have high rates of human papillomavirus (HPV) infection and an elevated risk of developing cervical cancer. However, information is lacking regarding several fundamental aspects of the association between HIV and HPV infections. A new study has found that, in women with HIV, the combination of plasma HI
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Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Apr-2005


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