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Other highlights in the August 17 JNCI

ith Klinefelter syndrome may have hypogonadism or other hormonal, physical, or developmental abnormalities. Case reports have suggested that these men may have an increased risk of several cancers, but information about the long-term cancer risks in these men is limited by the lack of large cohort studies.

To examine the cancer risks among men with Klinefelter syndrome, Anthony J. Swerdlow, D.Sc., of the Institute of Cancer Research in Sutton, England, and colleagues conducted a cohort study, following 3,518 men who had been diagnosed with the syndrome in Britain between 1959 and 2002. They compared cancer incidence and mortality among these men with that of men in the British population.

Compared with the general population, men with Klinefelter syndrome had higher mortality from lung cancer, breast cancer, and non-Hodgkin lymphoma and lower mortality from prostate cancer. Mortality from breast cancer among men with 47,XXY mosaicism and mortality from non-Hodgkin lymphoma among men with a 48,XXYY constitution were particularly high. The authors conclude that these results support a hormonal etiology for breast cancer in men and for prostate cancer.

Contact: Nadia Ramsey, Science Press Officer, Institute of Cancer Research, 44-207-153-5359, nadia.ramsey@icr.ac.uk

Study Examines Racial Disparities in Colon Cancer Treatment

Elderly black and white colon cancer patients are equally likely to consult with medical oncologists, but they do not receive recommended adjuvant treatment at the same rates after this consultation, according to a new study.

Studies have shown that black patients are less likely than white patients to receive screening and diagnostic tests and some treatments. A 2001 study, published in the Journal of the National Cancer Institute, reported that black patients were less likely than white patients to receive recommended chemotherapy for stage III colo
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Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
16-Aug-2005


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