Other highlights in the December 20 JNCI

Breast Cancer Stem Cells May Resist Radiation Treatment

The population of breast cancer cells that gives rise to a tumor may be relatively resistant to radiotherapy and may even increase when given multiple treatments of radiation, a new study shows.

In the last several years, researchers have discovered a small population of so-called cancer-initiating cells (also called cancer stem cells) in several cancers. These cells can self-renew and maintain the growth of a tumor, whereas its daughter cells cannot. Scientists are studying the properties of cancer-initiating cells because the destruction of these cells is likely necessary for the successful treatment of a cancer.

To test the response of breast cancer-initiating cells to radiation treatment, Tiffany M. Phillips, William H. McBride, Ph.D., D.Sc., and Frank Pajonk, M.D., Ph.D., of the David Geffen School of Medicine at the University of California, Los Angeles, exposed such cells and normal breast cancer cells to a single or multiple doses of radiation.

More cancer-initiating cells survived radiation treatment than did the other breast cancer cells. For example, 46% of cancer-initiating cells survived treatment with 2 Gray of radiation compared with 20% of normal breast cancer cells. When cells were given clinical doses of radiation (3 Gray) each day for 5 days, the proportion of cancer-initiating cells increased. This, the scientists found, may happen because radiation treatment seems to activate a specific signaling pathway that prompts the cancer-initiating cells to self-renew.

In an editorial, Maximilian Diehn, M.D., Ph.D., and Michael F. Clarke, M.D., of the Stanford University School of Medicine, note that, among other limitations, the new study was conducted with tissue culture cells, which may not mimic the actual conditions of a tumor in a person. Nevertheless, the findings are provocative, they write. "The findings have important clinical implic

Contact: Andrea Widener
Journal of the National Cancer Institute

Page: 1 2 3 4 5

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights from the March 21 JNCI
10. Other highlights in the March 7 JNCI
11. Other highlights in the Feb. 21 JNCI

Post Your Comments:

(Date:6/4/2019)... ... 04, 2019 , ... Harper was three years old when her owners took ... which caused painful osteoarthritis in the joints. She was referred to a veterinary ... The surgical specialist, Dr. Christopher Eich of Southern California Veterinary Specialty Hospital , ...
(Date:6/4/2019)... ... , ... Lajollacooks4u is delighted to announce it has been named as one ... given only to businesses that have achieved consistently outstanding traveler reviews on TripAdvisor, as ... To qualify for the Certificate of Excellence –- an award that only 10 percent ...
(Date:6/1/2019)... Md. (PRWEB) , ... May 31, 2019 , ... ... firm Wilson Sonsini Goodrich & Rosati recently invested in BioFactura’s $6M Series B ... BioFactura is now securing value-added institutional investors who bring significant financial and business ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... ... of the Diopsys® ffERG/Photopic Negative Response vision test, a new full ... 2050, it is estimated that 6.3 million Americans will have glaucoma, with black ...
(Date:5/2/2019)... ... ... Stay on top of current hot topics through free webinars presented by ... is free, so be sure to register today to save your place! Participate in ... see our upcoming webinars: , CLINICAL TRIALS , May 7 – Oncology Clinical Trials ...
(Date:4/25/2019)... , ... April 23, 2019 , ... Frank is an albino, deaf Great Dane. His ... want him due to his health issues. Despite his hearing impairment, he was always an ... the two would play all day, every day. As the two grew, playtime became rougher ...
(Date:4/16/2019)... ... April 16, 2019 , ... On April ... partner, the U.S. Army Center for Environmental Health Research (USACEHR), with an award ... , Blue Sources, a veteran-owned company located at the Frederick Innovative Technology Center, ...
Breaking Biology Technology:
Cached News: