Other highlights in the February 1 JNCI

STAT1 Protein Associated With Tumor Growth in Head and Neck Cancers

A new study suggests that the protein STAT1, which negatively regulates cell growth and survival, can suppress tumor growth in squamous cell carcinoma of the head and neck (SCCHN) tumors. When the promoter region of the STAT1 gene is chemically modified by a process called promoter hypermethylation, thereby inhibiting STAT1 expression, the result can increase SCCHN tumor growth.

Researchers have suggested that dysregulation of STAT proteins could play a role in tumor formation and growth. The exact mechanism by which STAT1 gene methylation is altered in SCCHN tumors had not been determined.

Jennifer Rubin Grandis, M.D., at the University of Pittsburgh, and colleagues compared expression of STAT1 in SCCHN tumors and in tissue samples from patients without cancer. They found that STAT1 expression was lower in tumors than in normal tissue. In separate laboratory experiments, they found that SCCHN cells ceased growing and died when STAT1 expression was increased above normal levels. They also found that STAT1 expression was reduced in many of the SCCHN tumors by a process called promoter hypermethylation. When they treated cells with a drug called azacytidine, which reverses hypermethylation, STAT1 expression increased and those tumor cells became more responsive to treatment with the cancer drug cisplatin. The authors suggest that STAT1 works as a tumor suppressor for SCCHN cells, but when expression is lowered, SCCHN tumors grow.

In an accompanying editorial, Heehyoung Lee, Ph.D., and Hua Yu, Ph.D., of the Beckman Research Institute in Duarte, Calif., write, "The present study reveals a novel regulatory mechanism for STAT1 in cancer. Their data show that the STAT1 promoter is hypermethylated in SCCHN tissues and cell lines and that demethylation of the STAT1 promoter can sensitize tumor cells to chemotherapeutic agent-induced apoptosis."


Contact: Ariel Whitworth
Journal of the National Cancer Institute

Page: 1 2 3 4

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights from the March 21 JNCI
10. Other highlights in the March 7 JNCI
11. Other highlights in the Feb. 21 JNCI

Post Your Comments:

(Date:7/1/2020)... (PRWEB) , ... July 01, 2020 , ... ... that it had completed the purchase of Teva-Takeda Pharmaceuticals’ packaging facility in Minakuchi, ... company’s existing Japanese clinical supply facility located in Kakegawa, the new 60,000-square-foot facility ...
(Date:6/28/2020)... ... June 25, 2020 , ... ... today announced that it has entered into a multi-year contract with Merus ... support their translational and clinical research strategy to discover and develop ground-breaking ...
(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions ... data services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: ... hospitalized patients with severe COVID-19. This is the first study of an XPO1 ...
Breaking Biology News(10 mins):
(Date:7/22/2020)... ... July 22, 2020 , ... Join experts from Reed Tech , Gary ... in a one hour live webinar on Thursday, August 13, 2020 at ... drugs and medical devices. Specifically, for medical devices, the NMPA has departments dealing with ...
(Date:7/10/2020)... LORTON, Va. (PRWEB) , ... July 08, 2020 ... ... laboratory testing services and products, announces a significant expansion of laboratory operations through ... robust collection for agencies implementing testing programs. , Bode-CARES provides ...
(Date:7/7/2020)... (PRWEB) , ... July 06, 2020 , ... ... Practices Awards. Entries from Roche, Eli Lilly, Bristol-Myers Squibb, the University of Chicago, ... 2003, Bio-IT World has hosted an elite awards program, highlighting outstanding examples of ...
(Date:6/28/2020)... , ... June 25, 2020 , ... ... racing to develop a vaccine or drug treatment. In an effort to better ... has publicly released the world’s largest imaging dataset portraying therapeutic compound effects from ...
Breaking Biology Technology:
Cached News: