HOME >> BIOLOGY >> NEWS
Other highlights in the February 16 JNCI

Trio of Papers Address Issues in Using Serum Proteomics for Detecting Ovarian Cancer

In 2002, a study reported that an analysis of protein patterns in a blood sample could be used to detect ovarian cancer. However, questions have been raised about whether the technology produces results that are reproducible and reliable enough for use as a screening test. A new study and two responding commentaries discuss these issues.

Keith A. Baggerly, Ph.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues examined the reproducibility of the proteomic pattern found in a previous study from a researcher at the State University of New York, Stony Brook, that used publicly available ovarian cancer datasets produced by Lance A. Liotta, M.D., Ph.D., of the National Cancer Institute, and Emanuel F. Petricoin III, Ph.D., of the U.S. Food and Drug Administration. Baggerly and colleagues maintain that the patterns, which were derived from blood samples to determine whether or not women had ovarian cancer, were not biologically plausible. In addition, they found that the method used in the Stony Brook study to classify patterns performed no better than chance. They conclude that the reproducibility of the proteomic profiling approach remains an open question.

In a commentary, Liotta, Petricoin, and colleagues respond to the study by Baggerly et al. They note that, because the parameters of their experiments changed for each of the publicly available datasets, they were not surprised that the patterns were different. They write that this discrepancy highlights the need for improved communication among scientists who produce and analyze data and for the establishment of a common platform and standardized operating procedures for this new technology so such studies can be compared across different laboratories.

A second commentary, from David F. Ransohoff, M.D., of the University of North Carolina at Chapel Hill, descr
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
15-Feb-2005


Page: 1 2 3 4

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights from the March 21 JNCI
10. Other highlights in the March 7 JNCI
11. Other highlights in the Feb. 21 JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2019)... N.C. (PRWEB) , ... January ... ... a clinical research organization headquartered in Morrisville, NC, providing full, customizable clinical ... with LaunchBio, Inc. to support educational programs for early stage life science ...
(Date:1/25/2019)... SAN FRANCISCO (PRWEB) , ... January 24, 2019 ... ... addition of Dr. Julia Oh, PhD, Assistant Professor of Microbiology at the Jackson ... and doctors from around the world, Dr. Oh will bring to uBiome expertise ...
(Date:1/24/2019)... CAMBRIDGE, Mass. (PRWEB) , ... January 23, 2019 ... ... announced today that it has received a Notice of Allowance from the United ... “Microparticle Multiplexing” filed by its affiliate company, DNA Medicine Institute (DMI). This application ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... ... 30, 2019 , ... Through its Microbiome Grant Initiative ... study design, planning, sample collection, and analysis to a team of researchers at ... study the interactions between gut microbial composition and cardiovascular health risks, such as ...
(Date:1/24/2019)... ... 2019 , ... Outsourcing trials to contract research organizations (CRO) ... RFP creation and management generally requires manual effort. Additionally, each vendor organizes tasks ... challenges can ultimately lead to study start delays and change orders because tasks ...
(Date:1/20/2019)... ... January 17, 2019 , ... The American Society of Gene & Cell Therapy ... , a new initiative for 2019. Designed by ASGCT committee volunteers in coordination with ... families, and the public on the status and promise of gene and cell therapies. ...
(Date:1/11/2019)... ... January 11, 2019 , ... Boekel Scientific ... collection of donor blood. This advanced and intuitive medical device was designed ... the functionality needed for the busiest donor stations with new-to-the industry features to ...
Breaking Biology Technology:
Cached News: