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Other highlights in the July 19 JNCI

DNA In Urine May Detect Bladder Cancer

Bladder cancer can be detected using a test that examines nine genes from DNA found in a patient's urine, a study reports.

David Sidransky, M.D., of the Johns Hopkins School of Medicine in Baltimore, Md., and colleagues tested the tumor DNA and the urine DNA of 15 patients with bladder cancer and 25 controls to identify biomarkers for this cancer. They then used these markers to see if they could detect bladder cancer in 160 patients and 69 controls.

The authors found that the genetic patterns in urine DNA matched those in tumor DNA. In this way, they were able to use DNA samples from urine as a noninvasive method to identify genetic markers for patients with bladder cancer.

They write that larger, long-term follow-up "will be required in future studies to define the impact of this technology on early detection, prognosis, and disease monitoring before clinical application."

Contact: Valerie Mehl, mehlva@jhmi.edu

High Pesticide Exposure Raises Risk of Liver Cancer

DDT exposure may increase a person's chance of developing liver cancer, a study shows.

Katherine A. McGlynn, Ph.D., of the National Cancer Institute in Rockville, Md., and colleagues identified 168 patients with liver cancer and 385 controls among participants in the Nutritional Intervention Trials in Linxian, China. They measured the subjects' pre-diagnostic serum levels of DDT and of product the DDT breaks down into, called DDE.

High levels of DDT in blood serum plasma were associated with an increased risk of developing liver cancer, particularly among individuals with low DDE levels. The authors suggest that direct DDT exposure may increase a person's risk of developing liver cancer or that some individuals may be more susceptible to the effects of DDT because of a decreased ability to break down DDT into
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Contact: Ariel Whitworth
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
18-Jul-2006


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