HOME >> BIOLOGY >> NEWS
Other highlights in the July 6 JNCI

Long-term Use of Aspirin, NSAIDs Associated With Decreased Risk of Prostate Cancer

A new study has found that long-duration regular use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen) may be associated with a reduced risk of prostate cancer.

Use of aspirin and other NSAIDs has been consistently associated with a reduced risk of colorectal cancer in epidemiological studies, and aspirin reduced risk of colorectal polyp recurrence in two randomized trials. There has also been some evidence from laboratory and epidemiological studies that NSAIDs might influence prostate carcinogenesis, although the association is unclear.

To determine whether use of NSAIDs is associated with a reduced risk of prostate cancer, Eric J. Jacobs, Ph.D., of the American Cancer Society in Atlanta, and colleagues studied more than 70,000 men participating in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. During the follow-up from 1992 to 1993 through August 2001, 4,853 cases of prostate cancer were diagnosed among these men.

Current use of aspirin or any NSAID was not associated with prostate cancer risk. However, long-duration regular use (30 or more pills per month for 5 or more years) of aspirin or any NSAID was associated with an estimated 18% reduction in the relative risk of prostate cancer. In the population studied, the age-adjusted rate of prostate cancer was 1,013 cases per 100,000 person-years among men who never reported NSAID use compared with 847 cases per 100,000 person-years among long-duration NSAID users.

"In this large prospective study, long-duration regular NSAID use was associated with a modest reduction in prostate cancer risk," the authors write. "In our view, it would be premature to consider reduced risk of prostate cancer a benefit of using aspirin or other NSAIDs because to date there are relatively few large observational studies and no randomized trials a
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
5-Jul-2005


Page: 1 2 3 4 5

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights from the March 21 JNCI
10. Other highlights in the March 7 JNCI
11. Other highlights in the Feb. 21 JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/23/2020)... ... August 21, 2020 , ... The August edition ... and is now available on the company’s global website. Crystallography Times—an electronic newsletter ... presenting current news and crystallographic research. , The latest issue of Crystallography ...
(Date:8/21/2020)... CARLSBAD, Calif. (PRWEB) , ... August 19, 2020 ... ... of both Salimetrics LLC and SalivaBio LLC, businesses dedicated to Salivary Bioscience for ... co-editor of the recently published book by Springer, " Salivary Bioscience: Foundations of ...
(Date:8/21/2020)... , ... August 20, 2020 , ... ... Hassan Movahhed , a Clinical Operations executive with expertise in clinical trial ... joined the firm as an Expert Consultant. Throughout his career, Mr. Movahhed has ...
Breaking Biology News(10 mins):
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/18/2020)... ... July 17, 2020 , ... ... firm for the life sciences and food industries, is pleased to announce that ... Clinical Research – Business Development. , Charles is an accomplished and results-driven sales ...
(Date:7/10/2020)... ... 2020 , ... In most research using the zebrafish model, ... in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. Over the past ... the zebrafish model to investigate the causes of leukaemia and its relationship with ...
(Date:7/7/2020)... ... , ... Bio-IT World has announced the winners of the ... of Chicago, Massachusetts General Hospital, Mission: Cure, and the Pistoia Alliance were honored. ... examples of how technology innovations and strategic initiatives can be powerful forces for ...
Breaking Biology Technology:
Cached News: