Transcription Factor May Help to Regulate Telomerase Activity in Malignant Gliomas
The transcription factor E2F1 may participate in the regulation of telomerase activity in malignant glioma cells, according to a new study.
Candelaria Gomez-Manzano, M.D., of the University of Texas M. D. Anderson Cancer Center in Houston, and colleagues investigated the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas, in glioma cell lines, and patients with malignant glioma. They found evidence that E2F1 may participate in the regulation of telomerase activity in malignant glioma cells and that E2F1 expression appears to be strongly associated with the survival of patients with malignant brain tumors.
Contact: Laura Sussman, Communications Office, M. D. Anderson Cancer Center, 713-745-2457, lsussman@mdanderson.org
Gene Variant May Contribute to Development of Non-Hodgkin Lymphoma
A new study has found that a genetic variant of the gene B-cell lymphoma 6 (BCL6) may contribute to the development of non-Hodgkin lymphoma (NHL).
Yawei Zhang, Ph.D., of the Yale University School of Medicine in New Haven, Conn., and colleagues examined the association between a particular genetic polymorphism in the BCL6 gene that could potentially alter BCL6 mRNA transcripts and NHL risk in a population-based casecontrol study of women living in Connecticut. The risk of NHL in women with the CC genotype was more than double that of women with the TT genotype. The authors conclude that their results support the hypothesis that this genetic variant is involved in the development of NHL.
Contact: Karen N. Peart, Yale Office of Public Affairs, 203-432-1326, karen.peart@yale.edu
Also in the November 2 JNCI: