HOME >> BIOLOGY >> NEWS
Other highlights in the November 3 JNCI

Method Could Improve Irinotecan Chemotherapy Effectiveness

Assessing how quickly the body metabolizes the drug midazolam combined with genotyping could help to optimize irinotecan chemotherapy, according to a new study.

Irinotecan has been approved for use as part of first- and second-line chemotherapy for colorectal cancer and also has moderate activity against breast cancer, relapsed or refractory non-Hodgkin lymphoma, and lung cancer. Response to the drug varies in different people because of variations in the enzymes that metabolize the drug, including cytochrome P450 3A4 (CYP3A4) and uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1).

Alex Sparreboom, Ph.D., of the National Cancer Institute, and colleagues demonstrated in 30 cancer patients that the speed at which the body metabolizes the drug midazolam was associated with CYP3A4 phenotype and is closely related to how quickly the body metabolizes irinotecan. They also found that a specific UGT1A1 mutation was associated with increased amounts of the active inrinotecan metabolite. They conclude that combining CYP3A4 phenotyping with UGT1A1 genotyping could assist with the optimization of irinotecan chemotherapy. The method is currently undergoing validation in a prospective study.

Contact: National Cancer Institute Press Office, 301-496-6641, NCIPressOfficers@mail.nih.gov

Height, Obesity, and Activity Level Associated With Endometrial Cancer Risk

Greater height and obesity and lower levels of physical activity are all associated with an increased risk of endometrial cancer, according to a new study.

Obesity is an established risk factor for endometrial cancer, and there has been some evidence that body mass at younger ages, weight change, height, and physical activity may also be associated with a woman's risk of this cancer. To investigate these possible associations, Leo J. Schouten,
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
2-Nov-2004


Page: 1 2 3 4

Related biology news :

1. Other highlights in the Aug. 7 JNCI
2. Other highlights in the July 24 JNCI
3. Other highlights from the July 10 JNCI
4. Other highlights in JNCI, June 26
5. Other highlights in JNCI, June 12
6. Other highlights from the June 6 JNCI
7. Other highlights in the May 16 JNCI
8. Other highlights from the April 18 Journal of the National Cancer Institute
9. Other highlights from the March 21 JNCI
10. Other highlights in the March 7 JNCI
11. Other highlights in the Feb. 21 JNCI

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... platform specifically designed for life science researchers to analyze and interpret datasets, ... Franklin, who made a major contribution to the discovery of the double-helix ...
(Date:10/11/2017)... ... ... Personal eye wash is a basic first aid supply for any work environment, but most ... you rinse first if a dangerous substance enters both eyes? It’s one less decision, and ... unique dual eye piece. , “Whether its dirt and debris, or an acid or alkali, ...
(Date:10/11/2017)... , Oct. 11, 2017  VMS BioMarketing, a leading ... a nationwide oncology Clinical Nurse Educator (CNE) network, which will ... need for communication among health care professionals to enhance the ... nurses, office staff, and other health care professionals to help ... breast cancer. ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... implantation and pregnancy rates in frozen and fresh in vitro fertilization (IVF) ... and maternal age to IVF success. , After comparing the results from the ...
Breaking Biology Technology:
Cached News: