HOME >> BIOLOGY >> NEWS
Painkillers may threaten power of vaccines

With flu-shot season in full swing and widespread anticipation of the HPV vaccine to prevent cervical cancer, a new University of Rochester study suggests that using common painkillers around the time of vaccination might not be a good idea.

Researchers showed that certain nonsteroidal anti-inflammatory drugs (NSAIDs), also known as cyclooxygenase inhibitors, react with the immune system in such a way that might reduce the effectiveness of vaccines.

The research has widespread implications: study authors report that an estimated 50 to 70 percent of Americans use NSAIDs for relief from pain and inflammation, even though NSAIDs blunt the bodys natural response to infection and may prolong it.

For years we have known that elderly people are poor responders to the influenza vaccine and vaccines in general, said principal investigator Richard P. Phipps, Ph.D., a professor of Environmental Medicine, and of Microbiology and Immunology, Oncology and Pediatrics. And we also know that elderly people tend to be heavy users of inhibitors of cyclooxygenase such as Advil, aspirin, or Celebrex. This study could help explain the immune response problem.

The study is available online in the Dec. 1, 2006, Journal of Immunology, and was funded in part by the National Institutes of Health. (See full study at: http://www.jimmunol.org/cgi/content/full/177/11/7811)

When a person is vaccinated, the goal is to produce as many antibodies as possible to effectively neutralize the infection. To do this, white blood cells called B-lymphocytes, or B cells, spring into action to produce those antibodies. B cells also serve as the immune systems memory for future protection against the illness.

But Phipps and colleagues discovered that human B cells also highly express the cyclooxygenase-2 (cox-2) enzyme, which is not intrinsically bad unless it is overproduced, causing
'"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
28-Nov-2006


Page: 1 2 3

Related biology news :

1. UF to lead research on life-threatening fungus
2. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
3. Smithsonian Fragmentation Project threatened by Amazon Colonization Plan
4. Satellite images show destroyed and threatened villages in Darfur
5. UCR biologist receives $1.75 million grant to study plant-threatening bacteria
6. Land conversion and climate threaten land birds
7. Climate change threatens wild relatives of key crops
8. DNA analysis suggests under-reported kills of threatened whales
9. 20 of worlds 162 grouper species threatened with extinction
10. G6PD deficiency is associated with significant protection against severe, life-threatening malaria
11. Regardless of global warming, rising CO2 levels threaten marine life

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/21/2019)... ... August 20, 2019 , ... Cutting Edge Spine, ... the spine, today announced the 510(K) clearance of its novel SI joint fusion ... proven to improve osseointegration through superior hydrophilicity and optimized surface chemistry, as demonstrated ...
(Date:8/15/2019)... ... August 15, 2019 , ... Deep Science Ventures ... Food and Agriculture practice, a new unit dedicated to building 100 companies over the ... raw materials and supply chains. , Deep Science Ventures was founded to create ...
(Date:8/14/2019)... ... August 14, 2019 , ... An upcoming episode of ... microbiome therapeutics are helping to promote normal immune function in order to prevent ... educate about the DECODE.DESIGN.CURE™ technology platform, which rapidly develops microbiome therapeutics in order ...
Breaking Biology News(10 mins):
(Date:6/26/2019)... ... June 26, 2019 , ... Alice Branton today released research ... physicochemical properties of Magnesium Gluconate, which can prove to be beneficial for treating Hypomagnesemia. ... characteristic differentiation peak, change in crystallite size , Over 142% increase in ...
(Date:6/12/2019)... ... June 12, 2019 , ... Leak Detection Associates ... the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, is excited to announce ... will grant exclusive rights for Zillion to represent LDA in all of China. ...
(Date:6/11/2019)... (PRWEB) , ... June 10, 2019 , ... ... announced IOPP will add 80 of its scientific journals to DeepDyve’s rental service ... content to DeepDyve’s continually expanding library of more than 20 million articles, sourced ...
(Date:6/11/2019)... ... June 11, 2019 , ... A study ... stem cells (MSC-EV) are able to incorporate into human CD34+ cells, modifying their ... mice, MSC-EVs also increased the cells’ ability to lodge into bone marrow. This ...
Breaking Biology Technology:
Cached News: