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Pall blood filtration technology removes prions that can cause TSEs

The study, entitled "Removal of exogenous (spiked) and endogenous prion infectivity from red cells with a new prototype of leukoreduction filter," published in the official journal of the AABB (Transfusion 2005; 45 (12): 1839-1844), shows that the filtration technology removes infectious scrapie prions. Scrapie is a TSE disease affecting sheep. The studies were conducted and authored by Samuel Sowemimo-Coker, PhD, Principal Scientist and Technical Director, Pall Medical in collaboration with scientists from the New York Institute for Basic Research, one of the world's leading prion research centers.

The research focused on three approaches to evaluate the performance of the Pall prion reduction filter. In the exogenous (spiking) phase of the study, scrapie-infected brain homogenates were added to human red blood cells and then passed through a prion removal filter. The results showed that prions were removed below the level of detection by the Western blot assay.

In another phase of the exogenous study, scrapie-infected brain homogenates were diluted to obtain a variety of concentrations of infectious prion. These varying concentrations were divided into a test (filtered) group and a control (non-filtered) group and injected into the brains of healthy hamsters. (The hamster is a typical model used to determine prion removal efficiency.) The results of this phase of the study found that the prion reduction filter removed 3.7 logs (over 99.9%) of the infectious prion.

In the endogenous infectivity phase of the study, which is the most relevant to transfusion-transmitted TSEs, whole blood was collected from symptomatic scrapie-infected hamsters. It was processed into red blood cell samples that were designated either as test (filtered) or control (non-filtered) groups and then injected into healthy hamsters. Endogenously scrapie-infected red blood cells that were not filtered transmitted disease to six of the 43 animals, while the filte
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Contact: Marybeth Nibley
marybethn@bycommunications.com
Pall Corporation
20-Dec-2005


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