HOME >> BIOLOGY >> NEWS
Pall blood filtration technology removes prions that can cause TSEs

The study, entitled "Removal of exogenous (spiked) and endogenous prion infectivity from red cells with a new prototype of leukoreduction filter," published in the official journal of the AABB (Transfusion 2005; 45 (12): 1839-1844), shows that the filtration technology removes infectious scrapie prions. Scrapie is a TSE disease affecting sheep. The studies were conducted and authored by Samuel Sowemimo-Coker, PhD, Principal Scientist and Technical Director, Pall Medical in collaboration with scientists from the New York Institute for Basic Research, one of the world's leading prion research centers.

The research focused on three approaches to evaluate the performance of the Pall prion reduction filter. In the exogenous (spiking) phase of the study, scrapie-infected brain homogenates were added to human red blood cells and then passed through a prion removal filter. The results showed that prions were removed below the level of detection by the Western blot assay.

In another phase of the exogenous study, scrapie-infected brain homogenates were diluted to obtain a variety of concentrations of infectious prion. These varying concentrations were divided into a test (filtered) group and a control (non-filtered) group and injected into the brains of healthy hamsters. (The hamster is a typical model used to determine prion removal efficiency.) The results of this phase of the study found that the prion reduction filter removed 3.7 logs (over 99.9%) of the infectious prion.

In the endogenous infectivity phase of the study, which is the most relevant to transfusion-transmitted TSEs, whole blood was collected from symptomatic scrapie-infected hamsters. It was processed into red blood cell samples that were designated either as test (filtered) or control (non-filtered) groups and then injected into healthy hamsters. Endogenously scrapie-infected red blood cells that were not filtered transmitted disease to six of the 43 animals, while the filte
'"/>

Contact: Marybeth Nibley
marybethn@bycommunications.com
Pall Corporation
20-Dec-2005


Page: 1 2 3

Related biology news :

1. High blood pressure, low energy -- a recipe for heart failure
2. Brain blood flow gives clues to treating depression
3. Study finds gender differences in renal and other genes contributing to blood pressure
4. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
5. Research aims to identify markers for menopausal women at risk for deadly blood clot
6. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
7. A low expression of MX2 gene exists in the white blood cells of narcoleptics
8. How a pain in the neck could be bad for your blood pressure
9. Penn researchers discover pathway that eliminates genetic defects in red blood cells
10. U-M team identifies gene that regulates blood-forming fetal stem cells
11. MicroRNA works with Ago2 protein to regulate blood cell development

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/13/2017)... 2017 UBM,s Advanced Design and Manufacturing event ... emerging and evolving technology through its 3D Printing and ... alongside the expo portion of the event and feature ... focused on trending topics within 3D printing and smart ... event will take place June 13-15, 2017 at the Jacob ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
Breaking Biology News(10 mins):
(Date:7/22/2018)... WESTMINSTER, Colo. (PRWEB) , ... July 21, 2018 , ... ... recent research workshop on the off-target movement of dicamba herbicides is available on the ... research protocols that will help all stakeholders better understand and manage factors contributing to ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... of a United States multicenter, prospective clinical study that demonstrates the accuracy ... test capable of identifying clinically significant acute bacterial and viral respiratory tract ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... its endogenous context, enabling overexpression experiments and avoiding the use of exogenous expression ... guides is transformative for performing systematic gain-of-function studies. , This complement to ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017  SkylineDx ... London (ICR) and University of Leeds ... to risk-stratify patients with multiple myeloma (MM), in a multi-centric ... The University of Leeds is the ... UK, and ICR will perform the testing services to include ...
Breaking Biology Technology:
Cached News: