HOME >> BIOLOGY >> NEWS
Pediatric burn victims' recovery, diabetes, metabolism aided by fenofibrate (Tricor)

San Diego (April 3, 2005) One of the immediate serious results of sudden extreme trauma or stress, including burns and even surgery, is insulin resistance, or diabetes. As a result, healing is delayed, especially in the case of severe burns, and since the body is unable to fully use blood sugar for energy, muscle tissue is broken down as the body scavenges for other possible energy sources.

However, children with severe flame burns of more than 40% body surface area showed "significantly improved whole body glucose uptake -- almost to normal levels -- after a two-week course of treatment with fenofibrate," according to lead researcher, Melanie Green Cree at the University of Texas Medical Branch, Galveston. (The UTMB trauma center last week treated about 20 adult victims, including several with burns from the British Petroleum refinery after an explosion that killed at least 15 workers and injured dozens more.)

Cree said trauma in children "seems to cause problems with fat metabolism, which in turn may cause insulin resistance. This insulin resistance can be ameliorated with 10-14 days of fenofibrate treatment, and it may significantly improve morbidity outcomes, healing rates, and decrease time spent in the intensive care unit."

Going into the experiment, "we felt that the fat metabolism in the children may be deranged by their burns," Cree said. "We hoped that improving fat metabolism with fenofibrate, which is traditionally used to lower plasma triglycerides, would improve the insulin sensitivity. There is conflicting data about the relationship between glucose and fat metabolism. However, acute burn trauma seriously affects both glucose and fat metabolism, and our results show that by increasing cell mitochondrial fat metabolism with fenofibrate (marketed as Tricor by Abbott Laboratories), glucose metabolism can also be improved," Cree reported.

*Paper presentation: "Fenofibrate improves glucose metabolism in pediatric burns pat
'"/>


3-Apr-2005


Page: 1 2 3 4

Related biology news :

1. Pediatric ritalin use may affect developing brain, new study suggests
2. Pediatric cancer stem cell identified: understanding the origin of ERMS
3. Pediatrics study shows no link between juice and childrens weight
4. Childrens Hospital Boston presents at the 2006 American Academy of Pediatrics National Conference
5. Childrens Hospital Boston presents at the 2006 Pediatric Academic Societies annual meeting
6. VIASYS Healthcare Neonatal Pediatric Fellowship Award
7. Pediatric center to offer novel rehabilitation approach for spinal cord injury
8. Pediatricians lack confidence in managing obesity, and their own weight might be an important factor
9. Pediatric cardiology researchers describe findings in neurologic outcomes, heart devices
10. No sign that ethnic groups genes cause diabetes, international research team says
11. Structure of enzyme offers treatment clues for diabetes, Alzheimers

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/20/2019)... ... June 19, 2019 , ... The ... Diseases Society of America Foundation, and the possibly millions of dollars of “high ... agents in AD, are a “welcome affirmation” of the need to investigate more ...
(Date:6/16/2019)... ... June 14, 2019 , ... Emtec, Inc.®, ... deliver a joint presentation with Versiti’s CIO at the Healthcare Industry User ... Shingle Creek Resort. , Versiti Vice President and Chief Information Officer, Lynne Briggs, ...
(Date:6/11/2019)... ... June 12, 2019 , ... With a rapidly ... to leverage the Geneious Biologics platform as a premium hub for bioinformatics and ... Abveris, says: “The Geneious team has done an excellent job accommodating our specific ...
Breaking Biology News(10 mins):
(Date:5/15/2019)... ... May 15, 2019 , ... Milton Hershey School® has named William ... work within the biomedical industry, where he is changing lives by creating solutions to ... “William Harding epitomizes the vision of our founders – Milton and Catherine Hershey – ...
(Date:5/14/2019)... , ... May 14, 2019 , ... Gateway Genomics ... effectively doubling its space from 2,500 to 5,000 square feet. , “This past ... DNA tests ,” says Gateway Genomics CEO, Chris Jacob. “The SneakPeek At-Home test, which ...
(Date:5/4/2019)... , ... May 03, 2019 , ... ... the President of the Dakila Pesquisas Association, the scientist and ufologist Urandir Fernandes ... in Brasília (DF). Urandir detailed the results of some research carried out by ...
(Date:5/2/2019)... ... 30, 2019 , ... The centuries old practice of brewing beer thrives today ... breweries, and even home brewing clubs scattered across the nation. , But proper ... mastered can produce a superb product. Students at South Dakota School of Mines ...
Breaking Biology Technology:
Cached News: