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Pediatric burn victims' recovery, diabetes, metabolism aided by fenofibrate (Tricor)

ients," 12:30 p.m.-3 p.m. Sunday April 3, Physiology 361.2/board #A317. On view 7:30 a.m. - 4 p.m.

Cree is presenting the research at the 35th Congress of the International Union of Physiological Sciences in San Diego, March 31 - April 5, 2005.

The entire research team includes: Melanie Green Cree, Alse Aarsland, David Chinkes, David N. Herndon and Robert R. Wolfe from the University of Texas Medical Branch and Shriners Hospital for Children, Galveston.

Surprising 70% of serious burn victims show high insulin resistance

Working with children at the Shriners Hospital for Children, Galveston, the team found that when the children were admitted, "a surprising 70% of children with greater than a 40% total body surface area flame burns have an insulin sensitivity almost half that of healthy children. We wanted to understand why this diabetes develops and to see if medication could reduce it," Cree said.

The study involved 18 child burn victims ages 4 to 14 years of age who were admitted within four days of injury to the Shriners tertiary burn center in Galveston. They were studied four days after their first and third excision and grafting surgeries. The patients were randomly assigned either to placebo or fenofibrate treatment after the first procedure. The fenofibrate (FEN) patients received 5mg/kg of fenofibrate once daily for 112 days. Whole body insulin sensitivity was measured with a clamp technique; stable isotopes of glucose were used to measure liver glucose release and leg glucose uptake was calculated from arterial and venous samples. "Both the liver and the muscle in the leg were examined to try to understand which organs were responsible for the changes in insulin sensitivity, Cree explained.

After treatment, there was no change in the placebo group, but whole body glucose uptake during the clamp, the measure of insulin sensitivity, improved in the FEN group (p = 0.02). Insulin should prevent gluco
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3-Apr-2005


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