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Pediatric burn victims' recovery, diabetes, metabolism aided by fenofibrate (Tricor)

se release from the liver, but at one week following the burn, and before treatment, only 60% of release was prevented in either group. Following treatment, suppression of glucose release by the liver increased to over 70% of normal in the FEN group, whereas it dropped to 50% in the placebo group.

Before treatment at one week post-burn, muscle did not respond much to insulin in terms of glucose uptake. After treatment with fenofibrate, insulin-stimulated glucose uptake improved in the FEN group, compared to no improvement in the placebo group.

Mode of operation and next steps, including non-burn trauma

Results of the clinical experiment "lead to the conclusion that fenofibrate increases whole body glucose uptake in pediatric burn trauma patients, and appears to work by enhancing liver and muscle insulin sensitivity," Cree said.

"Even greater implications would be to do similar studies in non-burn trauma patients or in surgical patents," she added. "Currently, intensive care units nationwide have been instituting protocols to keep blood glucose levels normal during recovery. However, if the insulin resistance itself could be treated, rather than just the high glucose, the possibility exists for improved outcomes beyond the insulin treatment. This perhaps could mean faster recoveries and fewer deaths in many situations," Cree said.

Already she said the research group is conducting "a high insulin protocol to tightly control blood glucose levels in the Shriners youth burn population, to see if the fenofibrate is more or less efficacious than this traditional high insulin treatment. At the same time, we are also partially blocking the stress response with a beta-blocker, and this also seems to improve insulin sensitivity," Cree noted

Funding and background. Robert Wolfe, professor in the Department of Surgery and Anesthesia at UTMB, started studying the hypermetabolic effects of burns at the Shriners hospital
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3-Apr-2005


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