HOME >> BIOLOGY >> NEWS
Penn leads $4 million grant to study gene-environment interactions in lung cancer

PHILADELPHIA - The University of Pennsylvania School of Medicine, in association with Pennsylvania State University Medical College and Lincoln University, has received $4.2 million to study gene-environment interactions that increase the risk of lung cancer in African American and Caucasian smokers and non-smokers. The funds were awarded from Pennsylvanias share of the national tobacco settlement for 2006-2007.

The award, which was announced by Governor Rendell last month, will fund the establishment of a Center for Gene-Environment Interactions in Lung Cancer directed by Steve Whitehead, PhD, Professor of Pharmacology. The study will be conducted under the Gene-Environment Initiative of Penns Center of Excellence in Environmental Toxicology (CEET), directed by Trevor M. Penning, PhD.

Lung cancer is the leading cause of cancer deaths in the adult U.S. population. This year alone 174,500 new cases of lung cancer will be diagnosed and almost as many deaths will result, notes Penning. Eighty-five to ninety percent of all lung cancer is seen in individuals who smoke cigarettes, yet only ten-percent of those who smoke will succumb to the disease. These statistics suggest that a significant gene-environment interaction exists.

Cigarette smoke contains two major classes of cancer-causing chemicals: those derived from nicotine and those derived from polycyclic aromatic hydrocarbons (PAHs). PAHs are also produced by burning fossil fuels and are ubiquitous environmental pollutants. PAHs are present in soot that is found at relatively high concentrations in the air we breathe in urban environments, explains Penning. Exposure to environmental PAHs may also account for lung-cancer incidence in people who have never smoked.

The researchers aim to enroll and compare 600 lung-cancer patients from Philadelphia, which has high concentrations of air pollutants, and 600 patients from Hershey, Pa., which has comparatively unpolluted air. In
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
27-Apr-2007


Page: 1 2 3

Related biology news :

1. Acute sleep deprivation leads to changes in nighttime urine production for men and women
2. Biodesign Institute leads innovative project to prevent cancer
3. Screening approach leads to discovery of gene linked to breast cancer
4. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
5. Study of unexplained respiratory infections leads researchers to new virus
6. FSU leads botanical research into 21st century: Deep South Plant Specimen Imaging Project
7. Old dinosaur research leads to new honor
8. Long-term marijuana smoking leads to respiratory complaints
9. Trusting your instincts leads you to the right answer
10. Childrens Hospital researcher leads multipronged attack on infant leukemia
11. How brain injury leads to seizures, memory problems

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/6/2019)... ... November 06, 2019 , ... In October, Massachusetts stem cell ... patients about a poorly disclosed deficiency in stem cell treatments. Throughout stem ... the treating stem cells. This problem affects all patients receiving stem cell ...
(Date:11/2/2019)... , ... October 31, 2019 , ... In this podcast, ... a successful career in research and consulting. , The Beyond the Lab Podcast is ... feature interviews from alumni who have jobs in the biomedical field — and in ...
(Date:10/30/2019)... BALTIMORE, Md. (PRWEB) , ... October 30, 2019 ... ... at the 12th Annual CBRNe Convergence in Nashville, TN from Tuesday, November 5, ... and military responses to CBRNe (chemical, biological, radiological, nuclear) and IED (explosive) threats. ...
Breaking Biology News(10 mins):
(Date:11/5/2019)... ... November 04, 2019 , ... ... manufacturing solutions for drugs, biologics, gene therapies, and consumer health products, today ... The technology enhances Catalent’s proven GPEx expression platform through multiple improvements, including ...
(Date:11/2/2019)... ... October 31, 2019 , ... Join Patrick ... a live webinar on Friday, November 15, 2019 at 1pm EST ... the science of profiling T-cell receptors (TCRs) and B-cell receptors (BCRs), has been ...
(Date:10/29/2019)... , ... October 28, 2019 , ... CaroGen Corporation ... , , Professor Jack R Wands, MD, of Brown University ... (Pfizer) , Professor Gil Mor, MD, PhD, of Wayne State University, formerly ...
(Date:10/22/2019)... , ... October 22, 2019 , ... nQ Medical, Inc. ... School’s 2019 Most Fundable Companies List which was announced at a showcase event yesterday ... million in annual revenue, strong business plans, and impressive near-term growth projections to be ...
Breaking Biology Technology:
Cached News: