HOME >> BIOLOGY >> NEWS
Penn leads $4 million grant to study gene-environment interactions in lung cancer

PHILADELPHIA - The University of Pennsylvania School of Medicine, in association with Pennsylvania State University Medical College and Lincoln University, has received $4.2 million to study gene-environment interactions that increase the risk of lung cancer in African American and Caucasian smokers and non-smokers. The funds were awarded from Pennsylvanias share of the national tobacco settlement for 2006-2007.

The award, which was announced by Governor Rendell last month, will fund the establishment of a Center for Gene-Environment Interactions in Lung Cancer directed by Steve Whitehead, PhD, Professor of Pharmacology. The study will be conducted under the Gene-Environment Initiative of Penns Center of Excellence in Environmental Toxicology (CEET), directed by Trevor M. Penning, PhD.

Lung cancer is the leading cause of cancer deaths in the adult U.S. population. This year alone 174,500 new cases of lung cancer will be diagnosed and almost as many deaths will result, notes Penning. Eighty-five to ninety percent of all lung cancer is seen in individuals who smoke cigarettes, yet only ten-percent of those who smoke will succumb to the disease. These statistics suggest that a significant gene-environment interaction exists.

Cigarette smoke contains two major classes of cancer-causing chemicals: those derived from nicotine and those derived from polycyclic aromatic hydrocarbons (PAHs). PAHs are also produced by burning fossil fuels and are ubiquitous environmental pollutants. PAHs are present in soot that is found at relatively high concentrations in the air we breathe in urban environments, explains Penning. Exposure to environmental PAHs may also account for lung-cancer incidence in people who have never smoked.

The researchers aim to enroll and compare 600 lung-cancer patients from Philadelphia, which has high concentrations of air pollutants, and 600 patients from Hershey, Pa., which has comparatively unpolluted air. In
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
27-Apr-2007


Page: 1 2 3

Related biology news :

1. Acute sleep deprivation leads to changes in nighttime urine production for men and women
2. Biodesign Institute leads innovative project to prevent cancer
3. Screening approach leads to discovery of gene linked to breast cancer
4. Alcohol use during pregnancy leads to greater risk of extreme preterm delivery
5. Study of unexplained respiratory infections leads researchers to new virus
6. FSU leads botanical research into 21st century: Deep South Plant Specimen Imaging Project
7. Old dinosaur research leads to new honor
8. Long-term marijuana smoking leads to respiratory complaints
9. Trusting your instincts leads you to the right answer
10. Childrens Hospital researcher leads multipronged attack on infant leukemia
11. How brain injury leads to seizures, memory problems

Post Your Comments:
(Date:10/15/2014)... a non-traditional biophysics textbook and it describes how life ... of discovery into biological systems and provides an understanding ... is about how our genes make proteins that control ... cells in an organism. It quantifies the principles of ... be found on both large and small scales. The ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market releases photos ... in Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. ... , CEO of NXT-ID thanked his investors and employees "for their ...
(Date:10/14/2014)... new study published in Cancer Research shows ... and colon cancers—can promote the development of skin cancers ... and survival of sun-damaged skin cells. , Previously considered ... proteins called sirtuins that help regulate genomic stability and ... SIRT6 helps repair DNA damage, which can lead to ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
(Date:10/25/2014)... This research report “Biodegradable Plastics Market ... Regenerated Cellulose, PCL), by Application (Packaging, Fibers, Agriculture, ... 2019”, defines and segments the global biodegradable plastics ... global volume and value. , Browse 75 Market ... Slides and in-depth TOC on “Biodegradable Plastics Market ...
(Date:10/25/2014)... A new way to produce engineered skin ... skin grafting technologies, it also speeds up the healing ... in the October issue of STEM CELLS Translational Medicine, ... that result from severe burns and chronic wounds. , ... elements. These wounds heal by contraction, with epithelization (the ...
(Date:10/25/2014)... and NEW YORK , Oct. ... ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a biopharmaceutical ... it has implemented a 1-for-50 reverse split of ... trading on Friday, October 24, 2014. PlasmaTech,s common ... new CUSIP number 72754H109 and temporary ticker symbol ...
(Date:10/25/2014)... , Oct 24, 2014 Research and ... "Epigenetics Market by Product , Research Area & by ... to their offering. In this report, ... of products, research areas, and end users. The product ... are enzymes, instruments & consumables, kits, and reagents. The ...
Breaking Biology Technology:Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 2Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 3Biodegradable Plastics Market Projected to $3,476.87 Million by 2019 - Report by MarketsandMarkets 4New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 2Global Epigenetics (VLA, WBA, NBA, RTA, Rotary-Wing Aircraft) Market - Forecast to 2019 3
Cached News: