HOME >> BIOLOGY >> NEWS
Penn researcher shows that DNA gets kinky easily at the nanoscale

PHILADELPHIA Scientists have answered a long-standing molecular stumper regarding DNA: How can parts of such a rigid molecule bend and coil without requiring large amounts of force? According to a team of researchers from the United States and the Netherlands, led by a physicist from the University of Pennsylvania, DNA is much more flexible than previously believed when examined over extremely small lengths. They used a technique called atomic force microscopy to determine the amount of energy necessary to bend DNA over nano-size lengths (about a million times smaller than a printed letter).

The findings, which appear in the November issue of the journal Nature Nanotechnology, illustrate how molecular properties often appear different when viewed at different degrees of magnification.

"DNA is not a passive molecule. It constantly needs to bend, forming loops and kinks, as other molecules interact with it," said Philip Nelson, a professor in Penn's Department of Physics and Astronomy in the School of Arts and Sciences. "But when people looked at long chunks of DNA, it always seemed to behave like a stiff elastic rod."

For example, DNA must wrap itself around proteins, forming tiny molecular structures called nucleosomes, which help regulate how genes are read. The formation of tight DNA loops also plays a key role in switching some genes off. According to Nelson, such processes were considered a minor mystery of nature, in part because researchers didn't have the tools of nanotechnology to examine molecules in such fine detail.

"Common sense and physics seemed to tell us that DNA just shouldn't spontaneously bend into such tight structures, yet it does," Nelson said. "In the conventional view of a DNA molecule, wrapping DNA into a nucleosome would be like bending a yardstick around a baseball."

To study DNA on the needed short length scales, Nelson and his colleagues used a technique called high-resolution atomic force micr
'"/>

Contact: Greg Lester
glester@pobox.upenn.edu
215-573-6604
University of Pennsylvania
3-Nov-2006


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... March 15, 2016 --> ... by Transparency Market Research "Digital Door Lock Systems Market - ... - 2023," the global digital door lock systems market in ... 2014 and is forecast to grow at a CAGR of ... small and medium enterprises (MSMEs) across the world and high ...
(Date:3/14/2016)... , March 14, 2016 NXTD ... growing mobile commerce market, announces the airing of a new ... starting the week of March 21 st .  The commercials ... including its popular Squawk on the Street show. --> ... on the growing mobile commerce market, announces the airing of ...
(Date:3/11/2016)... 11, 2016 http://www.apimages.com ) - --> ... is available at AP Images ( http://www.apimages.com ) - ... used to produce the new refugee identity cards. DERMALOG will be ... CeBIT in Hanover next week.   --> ... be used to produce the new refugee identity cards. DERMALOG will ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... , ... May 25, 2016 , ... ... a Thai delegation at BIO 2016 in San Francisco. Located at booth number ... be available to answer questions and discuss the Thai biotechnology and life sciences ...
(Date:5/25/2016)... ... May 25, 2016 , ... The ... by the Office of the National Coordinator for Health IT (ONC) outlining a ... clinically relevant data were available when and where it was needed. The organization ...
(Date:5/25/2016)... ... 2016 , ... Lady had been battling arthritis since the age of two ... knee. Lady’s owner Hannah sought the help of Dr Jeff Christiansen of Superior ... cruciate ligament and help with the pain of Lady’s arthritis. Dr Christiansen suggested that ...
(Date:5/24/2016)...   MedyMatch Technology Ltd ., the data analytics healthcare ... support tools in the emergency room, announced today that it ... Technology Industries (IATI) BioMed Conference. The Conference ... National Life Sciences and Technology Week, and is being held ... Tel Aviv, Israel . Gene Saragnese ...
Breaking Biology Technology:
Cached News: