HOME >> BIOLOGY >> NEWS
Penn researchers discover how key protein stops inflammation

PHILADELPHIA Researchers at the University of Pennsylvania School of Medicine recently identified how a regulatory protein called Bcl-3 helps to control the bodys inflammation response to infection by interfering a critical biochemical process called ubiquitination. While previous studies suggested Bcl-3 plays a role in immunity, this is the first report that Bcl-3 regulates inflammation by blocking ubiquitination.

Their findings, published in Science, open new avenues of exploration for developing therapies to treat infectious or inflammatory diseases, such as sepsis, diabetes, and rheumatoid arthritis.

The novelty of our study is the discovery that Bcl-3 acting on gene expression has a profound effect on inflammation, says Ruaidhri Carmody, PhD, Senior Research Investigator in the Department of Pathology and Laboratory Medicine and first author of the Science paper. By mimicking Bcl-3 activity, we may be able to create an artificial way to block the inflammatory response.

In the laboratory of senior author Youhai Chen, PhD, Associate Professor of Pathology and Laboratory Medicine, Carmody and others searched for clues as to how Bcl-3 controls inflammation by examining how Bcl-3-deficient mouse cells respond to infection. Their studies revealed that Bcl-3 interacts with p50, a protein that inhibits gene transcription by binding to DNA.

p50 turns off the DNA region coding for inflammation, halting the response to infection, explains Chen. Without Bcl-3, Chen says p50 cannot stop the inflammation response, but instead will become degraded very fast, through ubiquintination.

Ubiquitination is an intracellular system of checks and balances, where cellular proteins are flagged for disposal. During exposure to infection, Bcl-3 appears to overrule the p50 ubiquitination, stabilizing the presence of p50 on DNA and halting inflammation.

Our study identifies another layer of information that controls the infla
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
7-Aug-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. ASU researchers partner with UOP to make biofuel for military jets a reality
3. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
4. Penn researchers discover pathway that eliminates genetic defects in red blood cells
5. U-M researchers find family of on switches that cause prostate cancer
6. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
7. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
8. MGH researchers confirm that bone marrow restores fertility in female mice
9. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
10. U-M researchers identify gene involved in breast cancer
11. Drug protects brain cells in Huntingtons disease model, researchers find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/9/2020)... DALLAS (PRWEB) , ... March ... ... by enterprises witnessed a steep growth rate of 64% last year, as ... to new research from Everest Group. Unfortunately, only 13% of all transformation ...
(Date:3/5/2020)... ... March 05, 2020 , ... Patients in need of new ... from Dr. Nickelice Brand of Dental Implants of Ocala. Same-day dental implants ... entirely new smile in just one day. This treatment utilizes advanced technology and Dr. ...
(Date:3/4/2020)... ... March 04, 2020 , ... ... announced the release of a unique, multi-dimensional nutraceutical formula for ocular blue light ... and natural plant biology to increase the retina’s healthy pigmentation and improve the ...
Breaking Biology News(10 mins):
(Date:3/3/2020)... ... March 03, 2020 , ... Ideal Implant ... latest breast implant technology at the IMCAS Innovation Shark Tank 2020 in Paris, ... dermatology, plastic surgery, and aesthetic science industries that promise to revolutionize medical practices ...
(Date:2/21/2020)... Ontario (PRWEB) , ... February 20, 2020 , ... In ... GMT/UK) join guest speakers from Synteract including Lisa Dilworth, BS, MS, Vice ... discussion about these challenges, with feasible strategies and solutions to support patients, sites and ...
(Date:2/21/2020)... ... February 21, 2020 , ... Pharmaceutical ... operations in order to adapt to new approaches like ‘Industry 4.0’ and continuous ... demand for personalized medicine and therapies. But with an industry with the world’s ...
(Date:2/13/2020)... ... 2020 , ... Arriello , a provider of market ... Vault Safety™ as part of the company’s continued growth in pharmacovigilance operations. ... safety information such as SUSARs and ICSRS, aggregate report production, signal management, and ...
Breaking Biology Technology:
Cached News: