HOME >> BIOLOGY >> NEWS
Penn researchers discover how microRNAs control protein synthesis

PHILADELPHIA While most RNAs work to create, package, and transfer proteins as determined by the cells immediate needs, miniature pieces of RNA, called microRNAs (miRNAs) regulate gene expression. Recently, researchers from the University of Pennsylvania School of Medicine determined how miRNAs team up with a regulatory protein to halt protein production. Results of the study were published recently in Cell.

Scientists estimate miRNAs have the ability to regulate the expression of approximately one third of human genes, and previous studies have linked abnormal activity of miRNAs to cancer and other diseases.

While scientists know that most miRNAs in mammals repress the translation of RNA to protein, the molecular steps by which they achieve regulation are largely unknown. By studying the relationship between human miRNAs and the regulatory protein Argonaute2 (Ago2), lead author Marianthi Kiriakidou, MD, Assistant Professor of Medicine, and others set out to uncover how miRNAs control protein synthesis.

Before interfering with protein production, miRNAs associate with proteins from the Argonaute (Ago) family. According to Kiriakidou, Ago proteins are at the heart of the miRNA regulatory pathway, due to their engagement with miRNAs.

The miRNA and Ago protein association dictates the way that miRNA regulates gene production. While there are four different proteins in the human Ago family, Kiriakidou and colleagues from Zissimos Mourelatos team focused on the interaction between miRNA and Ago2. Ago2 stands out among the four mammalian Ago proteins since it is the only Ago protein able to mediate RNA interference by inhibiting gene expression.

Under normal conditions, the initiation of protein synthesis is kicked off when a protein called eIF4E binds to the front end, or cap, of messenger RNA. With eIF4E in place, a cascade of protein-protein and protein-RNA interactions allows the manufacturing of proteins to begi
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
9-Jul-2007


Page: 1 2

Related biology news :

1. Innovative tagging technique may help researchers better protect fish stocks
2. Penn researchers discover how key protein stops inflammation
3. ASU researchers partner with UOP to make biofuel for military jets a reality
4. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
5. Penn researchers discover pathway that eliminates genetic defects in red blood cells
6. U-M researchers find family of on switches that cause prostate cancer
7. 2007 EURYI: 20 young researchers to receive Nobel Prize-sized awards for breakthrough ideas
8. Pets could be source of multiresistant bacteria infections in humans, MU researchers investigate
9. MGH researchers confirm that bone marrow restores fertility in female mice
10. Smithsonians National Zoo researchers use electronic eggs to help save threatened species
11. U-M researchers identify gene involved in breast cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/24/2017)... WASHINGTON , April 24, 2017 ... counsel and partner with  Identity Strategy Partners, LLP ... "With or without President Trump,s March 6, ... Foreign Terrorist Entry , refugee vetting can be instilled ... refugee resettlement. (Right now, all refugee applications are ...
(Date:4/17/2017)... MELBOURNE, Florida , April 17, 2017 ... security technology company, announces the filing of its 2016 Annual Report ... Securities and Exchange Commission. ... Report on Form 10-K is available in the Investor Relations section ... well as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... May 17, 2017 , ... USDM Life ... for the life sciences and healthcare industries, is honored that Jay Crowley ... Devices conference in Brussels, Belgium. , Crowley played a crucial role in the ...
(Date:5/18/2017)... ... May 17, 2017 , ... G-CON ... their Chief Executive Officer, Maik Jornitz, was recognized as a Top 10 Industry ... celebrates 100 individuals “involved in bettering the pharma industry and bringing life-changing medicines ...
(Date:5/18/2017)... ... ... Sherley, was notified earlier this year that his company Asymmetrex had been selected ... Silicon Review , he was not surprised as others might be. Sherley says, “I ... Silicon Valley was particularly meaningful. Our selection by The Silicon Review may ...
(Date:5/16/2017)... ... May 16, 2017 , ... ... its new ProxiMeta™ Hi-C metagenomic deconvolution service. ProxiMeta enables researchers to obtain ... DNA extraction—speeding research insights at lower cost. , “We’re very excited about ...
Breaking Biology Technology:
Cached News: